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ISSUES RELATED TO PUBLICATION OF health system-based investigations

ISSUES RELATED TO PUBLICATION OF health system-based investigations. sSD Fihn MD MPH Stephan D Fihn MD MPH Professor of Medicine and Health Services University of Washington Deputy Editor, JAMA Network Open. What Journal Editors (Really) Want.

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ISSUES RELATED TO PUBLICATION OF health system-based investigations

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  1. ISSUES RELATED TO PUBLICATION OF health system-based investigations sSD Fihn MD MPH Stephan D Fihn MD MPH Professor of Medicine and Health Services University of Washington Deputy Editor, JAMA Network Open

  2. What Journal Editors (Really) Want • “Hot” or innovative topics relevant to readership • For general journals this includes effectiveness studies • High likelihood of citation • Strong methodology • Clear and concise writing • Adherence to reporting guidelines, e.g, CONSORT, STROBE, PRISMA, SQUIRE, etc. (http://www.equator-network.org/) • Measured interpretation of results

  3. Increasing attention to lay press & social media

  4. Methodologic Issues • Registration • Premier journals will not consider unregistered trials • Predefined analyses • Concerns about “data-dredging” • Statistical testing • “p values” as “significant” increasingly controversial. Also need to consider: • Sample size • Clinical significance • Effect size

  5. Other Issues • Other Statistical issues • Multiple comparisons • Unit of analysis: Pts. vs. sites • Hierarchical clustering • Evolving study designs • Adaptive/pragmatic designs • Adaptive randomization • Generalizability • Single vs. multiple site • Reproducibility • Avoiding unsupported causal inference • Open Access

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