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Mechanisms to induce autoimmune diseases

Mechanisms to induce autoimmune diseases. 1- Sequestration . 2- Crypticity . 3- Molecular Mimicry . 4- Polyclonal activation . 5- Inappropriate expression of MHC by Cytokine disregulation . 6- Failure of suppression . 7- Carrier effect. Immunopathogenesis:.

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Mechanisms to induce autoimmune diseases

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  1. Mechanisms to induce autoimmune diseases 1- Sequestration . 2- Crypticity . 3- Molecular Mimicry . 4- Polyclonal activation . 5- Inappropriate expression of MHC by Cytokine disregulation . 6- Failure of suppression . 7- Carrier effect .

  2. Immunopathogenesis: Cellular(Th1, Tc, NK) or AutoAb(Th2,B)block or support or Imm.complex 1- AutoAb: (Agonist or Antagonist). • Graves’ disease(thyrotoxicosis): AutoAb TSH-R T3&T4(Agonist). • Myasthenia Gravis: AutoAb Ach.R Muscle weakness(antagonist). Bronchial Asthma : AutoAb  adrenergic R . • [ Insulin ] & [ glucose] in blood : AutoAb Insulin R • Lambert Eaton syndrome : AutoAb Pre-synaptic Ca channels . • Guillain – Barre syndrome ; AutoAb Na channels . • Pernicious anemia : AutoAb IF (secreted from Parietal cell ) Vit . B12

  3. Immunological Approach for therapy of Autoimmune diseases : 1- Drugs : • Immunosuppressive . • Anti-inflammatory .

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