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Prof. A. M. Vollmar PD Dr. V. M. Dirsch Thomas Roos Nancy Lopez

WP 5: Cardiovascular diseases 5.1: The Interaction of garlic with mediators of inflammation. Prof. A. M. Vollmar PD Dr. V. M. Dirsch Thomas Roos Nancy Lopez. Deliverables.

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Prof. A. M. Vollmar PD Dr. V. M. Dirsch Thomas Roos Nancy Lopez

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  1. WP 5: Cardiovascular diseases 5.1: The Interaction of garlic with mediators of inflammation • Prof. A. M. Vollmar • PD Dr. V. M. Dirsch • Thomas Roos • Nancy Lopez

  2. Deliverables • Publication on the influence of garlic on the expression of adhesion molecules and its relevance to the atherosclerotic process • Publication on the influence of garlic on cytokines, NF-B, and TGF-b1 as important factorsinfluencing the cellular mechanisms of atherosclerosis

  3. Eur J Nutr., in press

  4. J. Nutr., 2003

  5. Additional targets • VSMC proliferation in atherosclerosis • Effect of garlic constituents on VSMC proliferation

  6. Physiological function: vasoconstriction vasorelaxation The blood vessel Endothelium Intima Smooth muscle cells Media Adventitia Connective tissue Robbins pathologic basis of disease 1999

  7. Vascular smooth muscle cells and their response to injury Smooth muscle cell mitosis Migration of smooth muscle cells to the intima Elaboration of extracellular matrix Endothelium Intima Media Robbins pathologic basis of disease 1999

  8. C: core of lipid; F: fibrous cap; L: llumen, moderately narrowed Robbins pathologic basis of disease 1999

  9. + Serum ? VSMC proliferation garlic Rat Primary rat aortic vascular smooth muscle cells (VSMC)

  10. n.s. n.s. n.s. 750000 500000 Number of cells 250000 serum 10% - + + + + 25 50 100 DADS (µM) Cell proliferation - DADS

  11. CS-activated cells Quiescent cells 25 µM DADS + CS 50 µM DADS + CS Events 100 µM RV + CS 100 µM DADS + CS DNA content Cell cycle analysis

  12. Outlook Human intervention study

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