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Genome-specific Curation

Specie: Anopheles gambiae PEST Genome size: 260 Mb Status: 3rd assembly and annotation NIAID funded. Species: Aedes aegypti Liverpool Genome size: 1.3 Gb Status: 1st assembly and annotation NIAID funded.

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Genome-specific Curation

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  1. Specie: Anopheles gambiae PESTGenome size: 260 MbStatus: 3rd assembly and annotationNIAID funded

  2. Species: Aedes aegypti LiverpoolGenome size: 1.3 GbStatus: 1st assembly and annotationNIAID funded

  3. Species: Culex pipiens quinquefasciatus JHBGenome size: 540 MbStatus: Shotgun sequencing completed ~8 XNIAID funded

  4. Species: Ixodes scapularis WIKELGenome size: 2.1 GbStatus: Shotgun sequencing in progress ~4 XNIAID funded

  5. Species: Peduculus humanus humanusGenome size: 100 MbStatus: Shotgun sequencing completed, ~8 XNHGRI funded

  6. Species: Glossina morsitans morsitansGenome size: 500-600 Mb (~7 Gb ??)Status: ~3 X coverage approved, > 40 K EST availableSanger Center

  7. Species: Phlebotomus papatasi, Lutzomyia longipalpisGenome size: Pp, ~170 MB, Ll ~ 300 Mb Status: BAC end and ESTs in progress, > 30 K EST avail.NHGRI and Sanger Center

  8. Species: Rhodnius prolixusGenome size: 670 MbStatus: Preliminary analysis of genomic DNANHGRI funded

  9. Species: Anopheles gambiae M and S Forms (6-10 other Anopheles spp. pending)Genome size: 260 MbStatus: Shotgun sequencing in progressNHGRI funded

  10. Genome-specific Curation • Anopheles gambiae PEST - Kitsos Louis • Aedes aegypti - Neil Lobo • Culex pipiens - Peter Arensburger • Ixodes scapularis - Cate Hill • Anopheles gambiae M/S - Nora Besansky • Other species - lead authors of white papers

  11. Discussion of Morning Topics Too many genomes VectorBase web site view VectorBase web site content AnoBase integration EST data independent of genomes CVs Expression/array data

  12. Population Data • Insecticide resistance data: High priority, directly linked to genomes • Population genetics data: Marker sets and population genetics data sets, directly linked to genomes • Population genetics of other species for which genomes are not available • Epidemiological/Ecological data: Parallel development by malaria groups in Africa • Vector and parasite population data

  13. Malaria Monitoring and Control Consortium (BMGF) • Malaria vector transmission and ecology data from 6 countries • Core malaria vector data sets to drive malaria simulation models • BMGF and MMCC objective of common data repository and format

  14. Population Data versus Genome Data

  15. Specie: Sabethes cyaneusGenome size:Status:

  16. Specie: Trypteroides bambusaGenome size:Status:

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