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National Institutes of Health AREA PROGRAM (R15)

National Institutes of Health AREA PROGRAM (R15). Thomas J. Wenzel Bates College, Lewiston, Maine. NIH AREA Program. $300K direct support (1-3 years) Match with institute or center within NIH Meritorious research Significant novel question or hypothesis Significant impact.

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National Institutes of Health AREA PROGRAM (R15)

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  1. National Institutes of Health AREA PROGRAM (R15) Thomas J. Wenzel Bates College, Lewiston, Maine

  2. NIH AREA Program • $300K direct support (1-3 years) • Match with institute or center within NIH • Meritorious research • Significant novel question or hypothesis • Significant impact

  3. Review Criteria • Significance – quality of research • Approach – experimental method • Innovation – novelty of work • Investigator – expertise/record in field • Environment – infrastructure to support work

  4. Components of Proposal Specific Aims (1 page) Research Strategy (12 pages)

  5. Research Strategy • Significance • Innovation • Approach – divide by each specific aim • Introductory paragraph • Justification and feasibility • Review relevant literature • Preliminary studies • Research design • Expected outcomes • Potential problems/Alternative strategies • Timetable • Future Directions

  6. Common Problems Significance or Innovations • Not significant, or exciting, or new research • Lack of compelling rationale for experiments • Incremental or low-impact research • Weak or little biological, biomedical, or behavioral relevance

  7. Common ProblemsExperimental Approach • Lack of clear, strong hypotheses, questions, or models • Too ambitious; too many aims proposed • Unfocused or unrelated aims; unclear or unintegrated goals • Limited or narrow aims; not addressing the important questions • Unnecessary experimental details for standard methods

  8. Not enough detail on novel methods, assays, or reagents • Insufficient on unconvincing preliminary data • Lack of appropriate controls; data difficult to interpret • Not directly testing hypothesis – more confirmatory data • Correlative or descriptive data – fishing expedition • Experiments not directed toward mechanisms • No discussion of alternative models or hypotheses • No discussion of potential pitfalls • No discussion of data interpretation or future directions

  9. Common ProblemsInvestigator • No/little demonstration of expertise or publications on proposed approaches • Low productivity; few recent or few primary author papers • Required collaborators not recruited – letters from collaborators missing

  10. Specific Aims • One-page summary of questions, goals, or hypotheses • Includes methods and how they will address and answer the hypotheses • Need to prioritize aims • Integrate specific aim with proposed approach

  11. Scientific Expertise • Publications in research area • Preliminary data • Collaborations when appropriate • Include letters of support • Include biographical sketch • Must be clear that PI is in charge of the project and collaborator only assisting

  12. Renewal Applications • Plan for renewal immediately upon receipt of grant • Fix renewal submission date in your head • Start short-term projects • Start long-term projects

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