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Clone. PFGE/ST. ADC. OXA-51. OXA-24. OXA-58. Imipenem MIC (mg/L). 6. Ab1 / 79. IS Aba1 –ADC-1. IS Aba1 – OXA -65/66/76/79. IS Aba2 – OXA -58–IS Aba3. >32. Ab2 / 79. IS Aba1 –ADC-1. IS Aba1 – OXA -65/66/76/79. IS Aba2 – OXA -58–IS Aba3. 4. Ab3 / 79. IS Aba1 –ADC-1.

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  1. Clone PFGE/ST ADC OXA-51 OXA-24 OXA-58 Imipenem MIC (mg/L) 6 Ab1 / 79 ISAba1–ADC-1 ISAba1–OXA-65/66/76/79 ISAba2–OXA-58–ISAba3 >32 Ab2 / 79 ISAba1–ADC-1 ISAba1–OXA-65/66/76/79 ISAba2–OXA-58–ISAba3 4 Ab3 / 79 ISAba1–ADC-1 OXA-65/66/76/79 OXA-58–ISAba3 Ab4 / 79 ISAba1–ADC-1 ISAba1–OXA-65/66/76/79 ISAba2–OXA-58–ISAba3 6 Ab5 / 79 ISAba1–ADC-5 OXA-65/66/76/79 1.5 Ab6 / 79 ISAba1–ADC-5 OXA-65/66/76/79 3 Ab7 / 79 ISAba1–ADC-5 OXA-65/66/76/79 OXA-24 >32 Ab8 / 79 ISAba1–ADC-5 ISAba1–OXA-65/66/76/79 0.75 Ab9 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab9 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab10 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab11 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab12 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab13 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab14 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab15 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab16 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab19 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab18 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab17 / 80 ISAba1–ADC-1 OXA-64/99/132 OXA-24 >32 Ab20 / 81 ISAba1–ADC-11 OXA-69/92/112 8 ISAba2–OXA-58–ISAba3 Ab21 / 81 ISAba1–ADC-11-likeG342R OXA-69/92/112 1.5 Ab22 / 81 ISAba1–ADC-11-likeG342R OXA-69/92/112 0.75 Ab23 / 81 ISAba1–ADC-11-likeG342R OXA-69/92/112 8 ISAba2–OXA-58–ISAba3 Ab24 / 81 ISAba1–ADC-11-likeG342R OXA-69/92/112 >32 ISAba2–OXA-58–ISAba3 Ab25 / 81 ISAba1–ADC-11-likeG342R OXA-69/92/112 8 ISAba2–OXA-58–ISAba3 Ab31 / 2 ISAba1–ADC-1 OXA-65/66/76/79 OXA-24 >32 Ab32 / 2 ISAba1–ADC-1-likeP240S OXA-65/66/76/79 OXA-24 >32 Ab33 / 2 ISAba1–ADC-1 OXA-65/66/76/79 OXA-24 >32 Ab34 / 2 ISAba1–ADC-1-likeP240S OXA-65/66/76/79 OXA-24 >32 Ab35 / 2 ISAba1–ADC-1-likeP240S OXA-65/66/76/79 OXA-24 >32 Ab36 / 2 ISAba1–ADC-1 OXA-65/66/76/79 OXA-24 >32 Ab37 / 2 ISAba1–ADC-1 OXA-65/66/76/79 OXA-24 >32 Ab26 / 2 ISAba1–ADC-1 OXA-65/66/76/79 OXA-24 >32 Ab27 / 2 ISAba1–ADC-1 OXA-65/66/76/79 OXA-24 >32 Ab28 / 2 ISAba1–ADC-1 OXA-65/66/76/79 OXA-24 >32 OXA-24 Ab29 / 2 ISAba1–ADC-25 OXA-206 >32 D2 Ab30 / 2 ISAba1–ADC-1 OXA-65/66/76/79 OXA-24 >32 Ab38 / 2 ISAba1–ADC-1 OXA-65/66/76/79 OXA-24 >32 CLUSTER D Ab39 / 2 ISAba1–ADC-25 ISAba1–OXA-109 4 Ab40 / 2 ISAba1–ADC-25 ISAba1–OXA-109 3 Ab41 / 2 ISAba1–ADC-25 ISAba1–OXA-109 4 Ab42 / 2 ISAba1–ADC-25 ISAba1–OXA-109 4 Ab43 / 2 ISAba1–ADC-25 ISAba1–OXA-109 12 D4 Ab44 / 2 ISAba1–ADC-25 ISAba1–OXA-201 4 Ab45 / 2 ISAba1–ADC-25 ISAba1–OXA-109 4 Ab46 / 2 ISAba1–ADC-1 OXA-65/66/76/79 OXA-24 >32 D5 Ab47 / 2 ISAba1–ADC-1-likeP240S OXA-65/66/76/79 OXA-24 >32 Ab48 / 2 ISAba1–ADC-1-likeP240S OXA-65/66/76/79 OXA-24 >32 Ab49 / 2 ISAba1–ADC-29/30/57 OXA-65/66/76/79 IS18–OXA-58 >32 D6 Ab50 / 2 ISAba1–ADC-29/30/57 OXA-65/66/76/79 IS18–OXA-58 >32 Ab51 / 2 ISAba1–ADC-29/30/57 OXA-65/66/76/79 IS18–OXA-58 >32 Ab52 / 2 ISAba1–ADC-25 ISAba1–OXA-109 4 D7 Ab53 / 2 ISAba1–ADC-29/30/57 OXA-65/66/76/79 OXA-24 >32 Ab54 / 15 ADC-2 ISAba1–OXA-64/99/132 ISAba2–OXA-58–ISAba3 16 Ab55 / 32 ADC-11-likeQ163K OXA-89/100 OXA-24 >32 Ab56 / 3 ADC-2-likeN260H/T264N OXA-71 OXA-24 >32 Ab57 / 3 ADC-2-likeN260H/T264N OXA-71 OXA-24 >32 G3 Ab58 / 3 ADC-2-likeN260H/264N OXA-71 OXA-24 >32 Genetic similarity index (%) 100 55 60 70 75 80 85 90 95 65 A1 A2 B C D1 D3 E F G1 G2 Figure S1. Dendogram showing the genetic diversityof A. baumannii as determined by PFGE and MLST; ADC, CHO and IS patterns; and imipenem susceptibility. The broken line corresponds to the cut-off level (80%) used to define single PFGE clones. Dotted squares mark the boundaries of cluster D.

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