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A Controlled Trial Investigating the Effects of Fitness Training in Multiple Sclerosis

A Controlled Trial Investigating the Effects of Fitness Training in Multiple Sclerosis. O’CONNELL R , MURPHY RM, COOKE G, FITZGERALD T. Kindly Funded by Biogen Pharmaceutical Company. Introduction. Sedentary Lifestyle (Ng & Kent-Braun 1997, Stuifbergen 1997) Age of Onset

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A Controlled Trial Investigating the Effects of Fitness Training in Multiple Sclerosis

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  1. A Controlled Trial Investigating the Effects of Fitness Training in Multiple Sclerosis O’CONNELL R, MURPHY RM, COOKE G, FITZGERALD T. Kindly Funded by Biogen Pharmaceutical Company

  2. Introduction • Sedentary Lifestyle (Ng & Kent-Braun 1997, Stuifbergen 1997) • Age of Onset • Social Outlet (Compston 1993) • Fatigue (Thompson, 1993) • Sutherland & Anderson, 2001, Neilson & Norgaard, 2002 • Positive effects on QOL, fitness, fatigue and strength (Petajan et al 1996)

  3. Aim To investigate the effects of a twelve week aerobic programme on the physical and psychosocial aspects of MS patients with mild disability

  4. Subjects Diagnosed, independently mobile, unchanged status for 3 months Random allocation of 24 patients: exercise group n=12 / control group n=12 Intervention 12 weeks: twice weekly in gym, once at home Circuit style training Heart Rate and RPE monitored Methods

  5. Methods Assessment: baseline, three months and F/U: • Aerobic Fitness: Modified Graded Exercise Test - HR and RPE • 50 Metre Walk Test • Questionnaires: Quality Of Life - FAMS (232) - MSIS-29 (145) Fatigue – MFIS (84) Analysis: Medians, upper and lower quartiles Kruskal-Wallis rank sum test

  6. Within-Group Changes from Baseline

  7. Changes from Baseline:Heart Rate

  8. Changes from Baseline:Rate of Perceived Exertion

  9. Changes from Baseline:Quality of Life

  10. Changes from Baseline:Fatigue

  11. Conclusion

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