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Anti-Coagulants

Anti-Coagulants. Physical Process of Clotting Chemical Process of Clotting Fibrin formation, extrinsic and intrinsic pathways Anti-coagulants Definition Heparin, Low molecular weight heparins, pentasaccharide Structure, properties, biochemical mechanism Coumarins and 1,3-indanediones

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Anti-Coagulants

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  1. Anti-Coagulants • Physical Process of Clotting • Chemical Process of Clotting Fibrin formation, extrinsic and intrinsic pathways • Anti-coagulants Definition • Heparin, Low molecular weight heparins, pentasaccharide Structure, properties, biochemical mechanism • Coumarins and 1,3-indanediones Structure, properties, biochemical mechanism MEDC 604 Anti-coagulants

  2. A) Physical Process B) Chemical Process Wound Wound aspirin antithrombins platelet activation factor Xa fibrinogen release thrombin release of of ADP generation thromboxane A2 thrombin prothrombin fibrin (monomers) vitamin K-dependent g-carboxylation of Glu residues Further activation of platelets ADP receptor antagonists GP IIb-IIIa receptor antagonists fibrin (polymer) Platelet aggregation coumarins CLOT The Clotting Process Taken from Desai UR (2004) Med. Res. Rev. 24, 151-181. MEDC 604 Anti-coagulants

  3. Physical Process of Clotting MEDC 604 Anti-coagulants

  4. Chemical Process of Clotting MEDC 604 Anti-coagulants

  5. Heparin and Low molecular weight heparins Structure and sequence MEDC 604 Anti-coagulants

  6. Pentasaccharide MEDC 604 Anti-coagulants

  7. AT + H AT:H AT-E + H E Biochemical Mechanism of Heparin Action MEDC 604 Anti-coagulants

  8. Direct Thrombin Inhibitors HIRUDIN – Isolated from leech, hirudino medicinalis. A polypeptide consisting of 65 amino acid residues that binds thrombin in the active site as well as another site called exosite I MEDC 604 Anti-coagulants

  9. Coumarins and 1,3-indanediones MEDC 604 Anti-coagulants

  10. Clinically useful coumarins and 1,3-indanediones MEDC 604 Anti-coagulants

  11. Biochemical Mechanism of Action MEDC 604 Anti-coagulants

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