1 / 61

Chemistry 2100

Chemistry 2100. Lecture 13. Metabolism. Stages of Catabolism. • digestion : hydrolysis • degradation : nutrients acetyl CoA • TCA Cycle : acetyl CoA CO 2 + NADH / FADH 2 • oxidative phosphorylation : NADH / FADH 2 ATP.

will
Download Presentation

Chemistry 2100

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Chemistry 2100 Lecture 13

  2. Metabolism

  3. Stages of Catabolism • digestion: hydrolysis • degradation: nutrients acetyl CoA • TCA Cycle: acetyl CoA CO2 + NADH / FADH2 • oxidative phosphorylation: NADH / FADH2 ATP

  4. Catabolic Pathways • Two principal types of compounds participating in the common catabolic pathway are: • AMP, ADP, and ATP: agents for the storage and transfer of phosphate groups. • NAD+/NADH and FAD/FADH2: agents for the transfer of electrons in biological oxidation-reduction reactions

  5. Adenosine Triphosphate Ad

  6. O O O Ad H O O P O P O P O 2 O O O O O O Ad O P O + O P O P O + 31.4 kJ/mol O O O

  7. Coupled Reactions (and why we need them)

  8. O O 16.7 kJ/mol + R C O H + H O R' R C O R' + H O 2

  9. O O O O Ad 10.5 kJ/mol + R C O H + O P O P O P O O O O O O O O Ad R C O P O + O P O P O O O O

  10. O O Ad R C O P O + H O R' O O O Ad + R C O R' + O P O 25.1 kJ/mol O

  11. O R C O H + H O R' + ATP O R C O R' + AMP + PP + 14.6 kJ/mol

  12. NAD+/NADH • NAD+ is a two-electron oxidizing agent, and is reduced to NADH. • NADH is a two-electron reducing agent, and is oxidized to NAD+. The structures shown here are the nicotinamide portions of NAD+ and NADH. • NADH is an electron and hydrogen ion transporting molecule.

  13. FAD/FADH2 • FAD is a two-electron oxidizing agent, and is reduced to FADH2. • FADH2 is a two-electron reducing agent, and is oxidized to FAD. • Only the flavin moiety is shown in the structures below.

  14. Carbohydrate Catabolism • glycolysis: glucose pyruvate acetyl CoA • TCA Cycle: acetyl CoA CO2 + NADH / FADH2 • oxidative phosphorylation: NADH / FADH2 ATP

  15. Glycolysis

  16. • H phosphofructokinase •

  17. • H •

  18. • H •

  19. • H • • H •

  20. • H • • H •

  21. • H • • H •

  22. • H • • H •

  23. • H • • H •

  24. H O O H C C NH 2 HPO -2 H OH + 4 dehydrogenase N -2 CH O PO 2 3 AD -2 O glyceraldehyde O O PO H H 3 3-phosphate C NAD + C NH 2 + H OH • • N -2 CH O PO 2 3 AD 1,3-bisphospho glycerate NADH

  25. 1,3 bisphospho glycerate

  26. 1,3 bisphospho glycerate

  27. 1,3 bisphospho glycerate 3-phospho glycerate

  28. 1,3 bisphospho glycerate 2-phospho glycerate 3-phospho glycerate

  29. H O 2-phospho glycerate

  30. H O 2-phospho glycerate

  31. pyruvate

  32. Anaerobic Glycolysis pyruvic acid (–)-lactic acid pyruvate lactic acid

More Related