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FcɛRI Signalling Pathway

FcɛRI Signalling Pathway. The Ligand : IgE. Mast and Basophil Cells. Fc receptors bind tail region of IgE antibodies. Histamine, proteases,. The Receptor. Tyrosine Kinases. Lyn. Syk. The Pathway. Binding of IgE Aggregation of receptors.

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FcɛRI Signalling Pathway

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  1. FcɛRI Signalling Pathway

  2. The Ligand : IgE

  3. Mast and Basophil Cells

  4. Fc receptors bind tail region of IgE antibodies. • Histamine, proteases,

  5. The Receptor

  6. Tyrosine Kinases Lyn Syk

  7. The Pathway • Binding of IgE • Aggregation of receptors

  8. Lyn binds beta unit of one receptor and transphosphorylates the beta ITAM, gamma ITAM, and Syk associated with adjacent receptor. Syk can also phosphorylate syk associated with adjacent receptor Syk activation Cascade of reactions Degranulation

  9. Allergy sufferers are at a lower risk of developing cancer

  10. Inverse association between IgE and malignancies • IgE-mediated immune responses against tumor cells  • IgE-based treatment options

  11. Histogram not generating all first passage times

  12. But it wasn't so bad • Bngl easy to understand • Easy to define chemical reactions • Can manipulate molecule concentrations • Can set time period of reaction

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