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cGMP-dependent Protein Kinase Signalling Pathways

cGMP-dependent Protein Kinase Signalling Pathways. Produced by Dr. Steven Pelech Kinexus Bioinformatics Corporation Copyright 2010. T58. T516. PDK1. PKG. PKC a. PKG Signalling. ?. cGMP. eNOS. PLCB3. PDE5A. GUCY1A3. S23. S1105. S106. S1177. S64. T1122. T58. T516. PKC a.

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cGMP-dependent Protein Kinase Signalling Pathways

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  1. cGMP-dependent Protein Kinase Signalling Pathways Produced by Dr. Steven Pelech Kinexus Bioinformatics Corporation Copyright 2010

  2. T58 T516 PDK1 PKG PKCa PKG Signalling ? cGMP

  3. eNOS PLCB3 PDE5A GUCY1A3 S23 S1105 S106 S1177 S64 T1122 T58 T516 PKCa PDK1 PKG PKG Signalling ? cGMP

  4. eNOS PLCB3 PDE5A GUCY1A3 S1105 S64 S1177 S23 S106 T516 T1122 T58 PKCa PDK1 PKG PKG Signalling ? cGMP NO

  5. eNOS PLCB3 GUCY1A3 PDE5A S1177 S64 S106 S1105 S23 T516 T58 T1122 PDK1 PKG PKCa PKG Signalling ? cGMP DAG NO Ca2+ IP3

  6. PKG Signalling www.phosphoNET.ca Substrate Substrate Full Name ProteinType Substrate Phospho- Effect of Kinase All Kinases Phosphatase Short Name Swissprot site Phosphorylation Affecting Affecting Affecting eNOS Endothelial nitric oxide Synthetase P29474 S1177 Phosphorylation increases PKG1 PKACa, synthetase enzymatic activity of PKBa/Akt1, eNOS. PKG1 GUCY1A3 Soluble guanylate cyclase Cyclase Q02108 S64 Phosphorylation inhibits PKG1 PKG1 cyclase activity. PDE5A cGMP phosphodiesterase 5 Phosphodiesterase O76074 S106 Phosphorylation increases PKG1 PKACa, PKG1 PPP1CA phosphodiesterase activity. PKG1 cGMP-dependent protein Protein-serine kinase, Q13976 T58 Phosphorylation increases PKG1 PKCa, PKG1 kinase 1, alpha AGC group, PKG family phosphotransferase activity and affinity for cGMP PLCB3 1-phosphatidylinositol-4,5- Enzyme, phospholipid Q01970 S1105 Phosphorylation inhibits of PKG1 PKG1 bisphosphate phospholipase C, G-protein-activated PLC- phosphodiesterase beta 3 phosphatidylinositol- beta3 activity. specific PLCB3 1-phosphatidylinositol-4,5- Enzyme, phospholipid Q01970 S26 Phosphorylation inhibits of PKG1 PKG1 bisphosphate phospholipase C, G-protein-activated PLC- phosphodiesterase beta 3 phosphatidylinositol- beta3 activity. specific PLCB3 1-phosphatidylinositol-4,5- Enzyme, phospholipid Q01970 T1122 Phosphorylation inhibits of PKG1 PKG1 bisphosphate phospholipase C, G-protein-activated PLC- phosphodiesterase beta 3 phosphatidylinositol- beta3 activity. specific PKG1 cGMP-dependent protein Protein-serine kinase, Q13976 T516 Phosphorylation increases ? ? kinase 1, alpha AGC group, PKG family phosphotransferase activity.

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