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The Life and Times of Anitvirals

The Life and Times of Anitvirals. By: Karen Summers Louise Pilsbury Jasmine Delaine Irfan Mekic Bethannie Jamerson. Viruses What are they!!!. Viruses, What are they!!!. How do they Spread?. Viruses are spread the same way as bacteria They can be spread through: Touch

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The Life and Times of Anitvirals

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  1. The Life and Times of Anitvirals By: Karen Summers Louise Pilsbury Jasmine Delaine IrfanMekic BethannieJamerson

  2. Viruses What are they!!!

  3. Viruses, What are they!!!

  4. How do they Spread? • Viruses are spread the same way as bacteria • They can be spread through: • Touch • Coughing/ Sneezing • Body fluids • Blood, saliva, ect. • Ex: hepatitis or AIDS

  5. How do Viruses Work? • Virus inject RNA/DNA into host cell’s cytoplasm • Uses the host cell to replicate • The new cell releases virus or infected cell • Change in cell structure causes symptoms

  6. How Viruses Work

  7. Antiviral and How it Work • Antiviral: Drug acting against viruses • Antiviral prevent the reproduction of viruses by: • Blocking reverse transcriptase enzyme activity with host cell • Alter host cells genetic material • Block ribosomes, preventing the virus from multiplying • Alter viruses’ binding site • Prevent virus from entering/ leaving the host cell

  8. Examples of Antiviral’s • Acyclovir • Works by altering the Cell’s genetic material • Structured similarly to abuilding block of DNA, tricking the virus into using it as a building block for viral DNA

  9. Examples of Antiviral’s • Amantadine • Works against influenza virus • Works by inhibiting enzyme active site, preventing virus from leaving the cell • The enzyme is needed to allow the viruses to stick to the host cell as it leaves

  10. How do AIDS work? • The virus invades white blood cells, specifically T-Cells • T-cells usually activate cells in immune system • Once inside cell, it makes viral-DNA from its RNA • The viral-DNA is programmed to make more viral particles and our released into the blood stream when the cell dies

  11. AIDS • HIV AID is a difficult virus to treat • This is because: • It attacks the white blood cells • billions of copies are made which allows for small mutations making the drugs ineffective. • Virus hides within host cells, sometimes dormant

  12. Treatments for AIDS • Non-nucleoside reverse transcriptase inhibitors • Disable protien needed for hiv to replicate • Ex. Sustiva • Protease Inhibitors • Disable protease • Ex. Reyataz • Fusion inhibitors • Block HIV’s entry into cell • Ex. Fuzeon • Integrase Inhibitors

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