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Update of China-ADNI

Explore the latest progress and findings of China-ADNI research including neuropsychological tests, biomarker studies, MRI protocols, PET scans, and an epidemiological survey on dementia. Also, discover the effects of acupuncture on Alzheimer's disease.

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Update of China-ADNI

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  1. Update of China-ADNI Kuncheng Li, MD. PhD. Dept. of Radiology,Xuanwu Hospital, Capital Medical University Beijing:100053, Email: cjr.likuncheng@vip.163.com WW-ADNI 2016,Toronto, Canada

  2. Outline • General information of China-ADNI • Progress of the China-ADNI

  3. China-ADNI Scientist advisory board Administration committee PI: Prof. Kuncheng Li, CMU CO-PI: Prof. Jun Wang, BJU CO-PI: Prof. Hongzheng Wang, BUMC MRI core Kuncheng Li PET core Fang Li Patholoy core Cuidi Wang Clinical core Liyan Qiao Biomarker and Genetics Core Jun Wang/Yan Zhang Biostatistics and Informatics core Li Wang DATA Post process Core Yong Fang Although joined WW-ADNI only 3 years of history, but we have made the gradual progress.

  4. Initial plan of China-ADNI

  5. Research plan Neuropsychological battery Biomarkers: Blood: Apo E polymorphism, Amyloid 40, 42, and tau CSF: Amyloid 40,42 and tau MRI: Multimodal PET: 18F-FDG 18F-AV-45

  6. 6 cities, 10 sites joined in this study, distributed in the northern, eastern, central and southwestern part of china mainland.

  7. Outline General information of China-ADNI Progress of the China-ADNI

  8. Enrolled Subjects 36 New subjects enrolled in the past 1 year, totally 121 cases:

  9. Enrollment in recent 3 years We have not figured out the drop-out rate

  10. Neuropsychological battery • Screening: MMSE, LM-I, LM-II, GDS, CDR，Hachinski • Baseline:ADAS-Cog，CWRT，MoCA, BNT, Rey AVLT(30’ Delay), Category fluency, Trial making test A&B,NPI, FAQ • 6 month: MMSE, CDR, MoCA, ADAS-Cog，E-cog,BNT, Rey AVLT(30’ Delay), Category fluency, Trial making test A&B, NPI, FAQ • 12 month,24 month 36 month:MMSE, LM-I, LM-II,DR,ADAS-Cog, E-cog, Rey AVLT(30’ Delay), MoCA,Category fluency Trial making test A&B,BNT, NPI , FAQ

  11. MMSE Score Follow-up MoCA Score Follow-up The MoCA score nearly unchanged in NC, but those of MCI and AD groups reduced beginning at 6 months, especially MCI groups decreased significantly at 12 months. The MMSE scores of NC and EMCI essentially unchanged, however, LMCI and AD slightly reduced.

  12. Blood biomarker study

  13. MRI Study Standard protocol for MRI scanning Quality control among different sites Improve the post-processing methods

  14. Scanning protocol of MRI 3D T1 volume Diffusion tensor imaging Resting state fMRI Arterial spin labelling Susceptibility weighted imaging

  15. A individual-level inline morphometry analysis Hippocampus and left temporal cortical matter are significant in distinguish AD and MCI from normal elderly, while the discrimination of MCI with NC seems more difficult A new brain template based on 2020 normal Han people

  16. On the rest state fMRI data Changes of hub, short distance, and long distance functional connectivity among AD, MCI, and NC groups pairwise contrastwas done Prefrontal cortex may play a key role in the AD functional connectivity compensation, whereas left anterior insula/frontal operculum and bilateral precuneus compromised in MCI indicate that the default mode network and dorsal attention network activity were involved in MCI period.

  17. PET Study AD MCI NC Nearly 80% cases had undergone the baseline examination of FDG-PET, the hypometabolic region could be depicted in AD and some MCI patients.

  18. 18F-AV-45-PET AD patient, 70 years, male. a large number of amyloid plaque depositionin in the brain, mainly involvedthe frontal, and parietal lobes.

  19. Epidemiological survey • From 2015.5 to 2016.5 • Three communities in the northern part of Sichuan province, • The surveyincluding 4120 inhabitants elder than 40yrs • Mobidity of AD and VD is 0.29% and 0.19% respectively.

  20. physical training, intellectual activity, and green tea are protective factor of dementia.

  21. Acupuncture effect on AD The increased connectivity of right middle frontal gyrus to left hippocampus and the superior/inferior temporal gyrus to right hippocampus in AD after acupuncture Wang, and Li.PLoS One. 2014,6;9(3):e91160

  22. MCI and ADpatients enrollment MRI scan Neuropsychological test Standard Acupuncture Treatment MRI scan Neuropsychological test A longitudinal clinical trial is in progress 120 MCI and AD patients was divided into true and false acupoints groups and neuropsychological test and rs-fMRI examination were performed, follow-up themthree years. To evaluationthe effect of acupuncture for MCI and AD.

  23. all the colleague of China-ADNI • the support from WW-ADNI Acknowledgements

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