MAP Kinase Signaling Pathways

1. MAP Kinase Signaling Pathways Mitogen-activated protein kinases (MAPKs) are serine-threonine kinases that mediate intracellular signaling. The multifunctional mitogen-activated protein kinase (MAPK) signaling system consists of separate pathways that function to control a number of different cellular processes such as gene transcription, metabolism, motility, cell proliferation, apoptosis, synaptic plasticity and long-term memory. These different downstream effectors are activated by the final MAPK components associated with the three main signaling pathways: • Extracellular-signal-regulated kinase (ERK) pathway • c-Jun N-terminal kinase (JNK) pathway • p38 pathway Each MAPK pathway contains a three-tiered kinase cascade comprising a MAP kinase kinase kinase (MAPKKK, MAP3K, MEKK or MKKK), a MAP kinase kinase (MAPKK, MAP2K, MEK or MKK) and the MAPK. This three-tier module mediates ultrasensitive switch-like responses to stimuli. These cascade protein kinase along with other functional components such as receptors, transducers, scaffolding protein and target protein form an extensive mitogen-activated protein kinase (MAPK) signaling toolkit, Specific components from this toolkit are then assembled into the different signaling pathways. MAP Kinase Signaling Pathways are ready at Creative Diagnostics for your research. http://www.creative-diagnostics.com/MAP-Kinase-Signaling-Pathways.htm