1.55k likes | 1.58k Views
CIRRHOSIS Pathophysiology & Complications. What is Cirrhosis?. Cirrhosis. Definition: Hepatic necrosis and degeneration combined with hepatic regeneration and fibrosis leading to Nodular formation. Normal liver functions Carbohydrate Metabolism Hypo- or hyperglycemia
E N D
CIRRHOSIS Pathophysiology & Complications
Cirrhosis Definition: Hepatic necrosis and degeneration combined with hepatic regeneration and fibrosis leading to Nodular formation
Normal liver functions • Carbohydrate Metabolism • Hypo- or hyperglycemia • Fatty Acids Metabolism • Lipid Transport • Hyper- or hypolipidemia • Proteins Metabolism • Serum Albumin • Vitamin K–Dependent Blood Coagulation Proteins • Bilirubin Metabolism • Bile Production • Fat-Soluble Vitamins • Detoxification • Drugs and hormones • Providing continual source of energy for entire body • Regulation of storage and modulate availability of systemic nutrients • Subject to hormonal modulation by endocrine organs • (Pancreas, adrenal gland, and thyroid, neuronal regulation)
1. Atrterial System 3. Venous System 2. Capillary System
5. Venous System 4. Second Visceral Capillary System 1. Atrterial System 2. First Visceral Capillary System 3. Venous System 3. Visceral Venous System 2. Capillary System
Normal Liver Histology CV 2-3 mmHg 6 mmHg PV
Portal Fibrosis = 1 None = 0 Bridging Fibrosis = 3 Cirrhosis = 4
Cirrhosis Causes (Etiology of chronic necrosis) + Host (Liver reaction) Lead to Cirrhosis & complications