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Physics 053 Handcrafting in the Nanoworld Instructor: Mike Falvo

Physics 053 Handcrafting in the Nanoworld Instructor: Mike Falvo. Carbon nanotube. Quantom Dot. Tuesday/Thursday 9:30. Myosin: Protein Machine. PHYS 053 : Handcrafting in the Nanoworld So what is this class about?. Nanoscience and Nanotechnology. Examples…. Human Made Nanomachines.

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Physics 053 Handcrafting in the Nanoworld Instructor: Mike Falvo

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  1. Physics 053Handcrafting in the NanoworldInstructor: Mike Falvo Carbon nanotube Quantom Dot Tuesday/Thursday 9:30 Myosin: Protein Machine

  2. PHYS 053 : Handcrafting in the NanoworldSo what is this class about?

  3. Nanoscience and Nanotechnology Examples…. Human Made Nanomachines Biological Motors

  4. We’ll learn about Nano-objects Carbon nanotubes, quantum dots, and other advanced nanomaterials Proteins, Biological motors, and other nanobiological systems Real and imagined human-made nanomachines

  5. Unique Properties of the Nanoscale:Nanoscience • Sticky (intermolecular forces) • Shaky (thermal energy) • Bumpy (Quantum effects)

  6. New Scientific Instruments and Techniques that have enabled Nanoscience • Scanning Probe Microscopy • Self-Assembly • Nano lithography

  7. New Technologies / Applications of Nanoscience • Nanoelectronics • molecular electronics • Quantum computing • Biomedical Tech • nanosensing • tissue engineering • Drug delivery • Nanomaterials • Stronger Lighter • Green Tech • Smart Materials

  8. Why Model Building? • We must learn the details of a complex structure well in order to build it (pro-active rather than passive) • Once built, these models are extremely useful for brainstorming and coming up with new intriguing questions

  9. What are we actually going to do? • Model Building • Readings/Discussions • Special Projects

  10. Is model building essential?Is it just for kids? Model Building is an essential part of all science. Ask Watson and Crick.

  11. Model Building is an essential part of all science. Models come in various forms. Physical Models, Computer Models, Mathematical Models…

  12. Languages of Science Math Spoken/Written “Orthorombic” “Covalent Bond” “Sub-atomic” Visual

  13. Discussion • We will discuss Reading Assignments, Building Projects, Lectures and what ever else we decide to discuss. • I expect pro-active participation in these discussions. What does this mean? • Have comments ready • Have questions ready • Have opinions to share You will be given a list of questions to think about and prepare discussion questions/comments. In some cases you will be assigned questions individually for which you will be responsible to lead a discussion .

  14. What are we actually going to do? • Model Building ~30% • Readings/Discussions ~30% • Lectures ~15% • Special Projects ~25%

  15. This Course is an Experiment This Course is a Group Project The success of this course depends on your curiosity and initiative

  16. Challenges: (for me and you) How do I teach an advanced subject like nanotechnology as a first year seminar? • A Little bit of basic Chemistry • A little bit of basic Biology • A little bit of basic Physics • A little bit of basic Materials Science • . . . ??? We’ll Stick to the big Picture and the Overarching Themes

  17. Challenges: (for you and me) • Be Proactive: • Ask questions, bring questions to class, Share your crazy ideas • Share your doubts or confusions. • Take some of the responsibility for your learning in this course

  18. Goals: Knowledge Goals • Become conversant in the diverse areas of Nanoscience • Understand the overarching themes of nanoscience and the potential and challenges of nanotechnology 2nd Order Goals • Become on informed citizen on nanoscience issues and science in general. How do scientist do what they do. • Use this class to help inform your long term goals (your career, your intellectual future…) Concrete Goals • Build cool Models • Our Dream: Building Amazing models that are of actual use to scientists in their research.

  19. INTRODUCTIONS • Who am I? • Graduate of University of Illinois at Urbana Champaign (BS Physics,1991) • Graduate of UNC-Chapel Hill (PhD Physics, 1997) • Research Professor in Physics • Who are you? • Why are you taking this class?

  20. Other Resources • Syllabus • Course Webpage • Blackboard

  21. Model Project 0 (MP0)Object in a Bag Today • We will split up into groups of 4 (research groups) • Each team will try to reconstruct the models in each bag using available materials Between today and Thursday • Read MP0 discussion questions on course webpage Thursday • Teams compare models and discuss. • Model refinement and completion

  22. Research Groups Group 3 Greg Stahr Christopher Kao Erik Thiede Elizabeth Moser Group 2 Dennis Cahill Skipper Iqbal Minh Huyn Alan Layer Group 1 Calvin. Lewis Jake Stringfield Michael. Beben Patrick Moseby Group 4 Patrick. Ross Zachary. McCaw TJ. Rider Elizabeth Wall Group 5 Alvaro. Aldana Steve. Garbin AsifKhan Stephen Cassells-Hansby

  23. Model Project Challenge The National Institutes of Health has challenged 5 world renowned nanoscience research labs help with a disease. It is suspected that there is something unusual about the structure of one of two proteins (they don’t know which). Each team is given two samples, one of each type of protein from a given individual. Only one team will get proteins from a diseased individual. Goals: 1. Determine which protein is responsible for the disease 2. Determine the normal (healthy) structure of each protein 3. Determine the pathological structure of the protein that causes the disease.

  24. Protein 2 Protein 1 Nanoscience Research Groups 1 2 3 4 5 Healthy Individuals NIH • 1. Determine which protein is responsible for the disease • 2. Determine the normal (healthy) structure of each protein • 3. Determine the pathological structure of the protein that causes the disease. Has Disease

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