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“. Rapid diagnosis must lead to the rapid initiation of an appropriate treatment. Web-Based Tools to Maximize a National Investment in the GeneXpert Jeff Takle , Dir. of Innovation @Abt Associates 2 nd African Regional Training Workshop on Xpert MTB/RIF July 24, 2013.
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“ Rapid diagnosis must lead to the rapid initiation of an appropriate treatment Web-Based Tools to Maximize a National Investment in the GeneXpert Jeff Takle, Dir. of Innovation @Abt Associates 2nd African Regional Training Workshop on Xpert MTB/RIF July 24, 2013
How Does it Work? Targeted alert messages eTB Manager or M&E tools USB modem, Wifi, Mobile phone, Manual upload Web database Electronic patient records
There Are Four Stable, Scaling-up Data Services Around the GeneXpert • GxAlert • Open source, dev in 2012 by Abt Associates • Incorporates diagnostics for TB and flu (GeneXpert) and HIV (PIMA) • Active in India and Nigeria; early stage in 5 countries • TBGxMonitor • Developed in 2011 by Univ. of Witwatersandin South Africa • Active in South Africa; early stage in 13 countries • XpertSMS • Open source, devin 2011 by IRD Pakistan • Active in Pakistan, Nepal, Kenya, Zimbabwe; early stage in 5 countries • RemoteXpert • Being developed by Cepheid, estimated launch December 2013 • Pilot tested in South Africa
What Does Each Software Do? • MOH • Case+Population level Management • Indicator reporting • MDR treatment • Drug demand / supply • Integration into existing National Health Information Systems (eTB*) • MOH messaging • Clinic / lab messaging • Patient messaging GxAlert XpertSMS • Labs • External Quality Assurance (EQA) • Instrument Verification • Pre-analytical, analytical and post-analytical evaluation • Errors and error rate (by user, module, and machine) • Providers • Cartridge expirations • Stockout management • Utilization vs. disease load • Deployment planning • Procurement, warranty, and service planning GxAlert TBGxMonitor RemoteXpert*
MOH Can Forecast Cartridge Needs By Observing Consumption Trends Avg. # tests/yr per device 438 Avg. Utilization per device 18% Est. Overpurchase in Year 1 -$103,114
MOH Can Identify Malfunctions Earlier and Reduce Patient Re-visits Number of Error Results, by Module A serious outlier Possible alert threshold Error Codes
MOH Can Set Thresholds for Errors: Above = Alert to Supervisor Focus attention where needed most Opportunity to identify “best practices” Possible alert threshold
Each is Relatively Inexpensive to Bring to National Scale • GxAlert ~$25,000 Yr1 to roll out nationwide and tech support existing software; Yr2 ~$10,000 • XpertSMS ~$25,000 Yr1 to roll out nationwide and tech support existing software; Yr2 ~$10,000 • TBGxMonitor available to complement NHLS/Wits DCS EQA program. Independent use cost TBD. • Cepheid’s RemoteXpert, cost TBD, Dec 2013 Each of these software is capable of being connected with the others so installing a mix of software is possible
Ways To Extend This Capability • Connect to an EMR (OpenMRS) • Connect to an M&E system • Connect to a case management tool (eTB Manager) • Connect to drug logistics program • Connect other diagnostic devices (Hain, MGIT, PIMA) • Automate portions of your indicator reporting
Challenges • Stable nationwide connectivity • Security • Stakeholder coordination
Why Include These Tools in Your GeneXpert Implementation? • Patient benefits: start treatment faster, reduce spread of drug resistant disease, recover sooner • Identify and track population drug resistance patterns of TB cases • Shorten diagnostic response time from months to minutes, getting patients into treatment faster • Reduce wasteand avoid stockouts through real-time forecasts • Dramatically improve data quality • Measure program adherence to the TB treatment protocols
Acknowledgements • MSH • KNCV • Nigeria NTP • India private sector labs • CHAI • IRD Pakistan • NHLS South Africa • USAID • CDC
Better patient treatment Faster response to MDR-TB More efficient TB logistics Prepared by: Martha Benezet martha_benezet@abtassoc.com Jeff Taklejeff_takle@abtassoc.com Download slide deck @ www.GxAlert.com