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C.Power - The World's Most Available Vitamin C

Learn about the importance of Vitamin C, its role in immunity, biosynthesis in poultry, and its impact on bone strength and eggshell quality. Understand how Vitamin C can mitigate the effects of stress and improve animal health.

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C.Power - The World's Most Available Vitamin C

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  1. C.Power  Worlds most availableVitamin C Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  2. C.Power  Worlds most availableVitamin C What is Vitamine C ? (1/2) • Centuries ago, sailors discovered that the disease scurvy could be prevented by sucking a lime or a lemon. • In the early 1930, the substance responsible for preventing scurvy was identified as L-ascorbic acid. • It is a fairly simple chemical, similar to hexose sugars such as glucose, with a chain of six carbon atoms. Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  3. C.Power  Worlds most availableVitamin C What is Vitamine C ? (2/2) • Birds are able to produce L-ascorbic acid in the kidneys from glucose and certain other six-carbon atom chains. (just like most animal species) • A few mammals and birds, notably man and guinea pigs, lack the enzyme L-gulonolactone oxidoreductase which catalyses the last stage in this synthesis. An exogenous, dietary supply of ascorbic acid is essential for such animals. Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  4. C.Power  Worlds most availableVitamin C Traditional supply of Vitamin C in poultry… 1)Poultry synthetisesit’sownVitamin C + 2)Inclusion of Vitamin C shows littleornoeffects Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  5. C.Power  Worlds most availableVitamin C Vitamin C The Facts Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  6. C.Power  Worlds most availableVitamin C • Enhances immunity of the animals • Inactivates harmful radicals produced from aerobic cellular metabolism and from various stressors • Maintains the functional and structural integrity of immune cells • Most important antioxidant in extra cellular fluids • Protects biological cell membranes against lipid peroxidation damage by eliminating peroxyl radicals • Mitigates the effects of stress • Activates and maintains the function of phagocyts • Enhances interferon synthesis • Deficiency impairs T-cell function Vitamine C and Immunity Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  7. C.Power  Biosynthesis of Ascorbic acid in Chicken (Diagrammatic) Worlds most availableVitamin C Biosynthesis of Vitamin C in Poultry (1/2) The biosynthesis (lag phase) of vitamin C in the chicken is inadequate to meet its physiological demands. In the chicken vitamin C is required for its function as a co-factor to convert vitamin D3 metabolite to a biologically active form of vitamin D3 known as Calcitriol to maintain calcium homeostasis. Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  8. C.Power Calcitriol Biosynthesis & Vit. C Supplement (Diagrammatic)  Worlds most availableVitamin C Biosynthesis of Vitamin C in Poultry (2/2) Commercial broiler chicken is deficient in Calcitriol during the first 2-3 weeks of age, which regulates calcium absorption, transportation and calcification process. Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  9. C.Power  Worlds most availableVitamin C Vitamin C and bonestrenght in Poultry As shown, adding vitamin C has far more impact on bone strenght than increasing the Vitamine D3 gift. Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  10. C.Power  Worlds most availableVitamin C Vitamin C and eggshellstrenght in oldlayers Note the big impact of added Vitamine C In comparison with Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  11. C.Power  Worlds most availableVitamin C Vitamin C and Heatstress 1/3 Adaptational Behaviour Nr.1: Respiratory Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  12. C.Power  Worlds most availableVitamin C Vitamin C and Heatstress 2/3 Adaptational Behaviour Nr.2: Feed- and waterintake Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  13. C.Power  Worlds most availableVitamin C Vitamin C and Heatstress 3/3 Hormonal consequences Decreased immunity Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  14. C.Power  Vitamin-C 0ppm Vitamin-C 150ppm Vitamin-C 300ppm 380 360 340 320 Feed Intake (g/chick/7days) 300 280 260 240 220 0 1 2 3 Numbers of stressors Worlds most availableVitamin C Stress and Feedintake & the impact of vitamin C • As the numbers of stressors increase, the feed intake of broilers decreases. • The supplementation of vitamin-C can help broilers to recovere from the stress- situation. • The supplementation of vitamin-C increases feed intake of broilers, stressed or not. Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  15. C.Power  Vitamin-C 0ppm Vitamin-C 150ppm 280 Vitamin-C 300ppm 260 240 220 Weight Gain (g/chick/7days) 200 180 160 140 0 1 2 3 Numbers of stressors (Mckee and Hamilton, 1995) Worlds most availableVitamin C Stress and weightgain & the impact of vitamin C • As the numbers of stressors increase, the weight gain of broilers will decrease. • The supplementation of vitamin-C can help broilers to recovered from a given stress-situation. • The supplementation of vitamin-C leads to increased weight gain of broilers, stressed or not. Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  16. C.Power  Worlds most availableVitamin C Vitamin C The Problem Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  17. C.Power  Worlds most availableVitamin C The problematic properties of Ascorbic Acid (1) 1/ Stability 2/ Lipophilic properties needed for a good intestinal absorption Plain Ascorbic Acid is missing…. 1. AA is a Hydrophilic antioxidant 2. AA inhibits melanogenesis 3. AA stimulate collagen synthesis 4. AA is an immunostimulator How much vitamin-C shall be added for broiler feed? Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  18. C.Power  Worlds most availableVitamin C The problematic properties of Ascorbic Acid (2) Allmost 100% of Vitamin C will be destroyed in the processing of the feed and will be digested before being absorbed…. Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  19. C.Power  Worlds most availableVitamin C Vitamin C The Solution Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  20. C.Power  Worlds most availableVitamin C Increasing Stability Ascorbyl-2 Polyphosphate (DSM) Ascorbic Acid L-Ascorbyl-2-Sulfate Magnesium Ascorbate phosphate C.POWER  1st 2nd 3th 4th 5th Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  21. C.Power  Worlds most availableVitamin C THE NEW APPROCH 1/ C.Poweris a Modified Ascorbic Acid 2/ C.Power is a Non-ionic, long-acting liquid form of vitamin C 3/ C.Power is a very powerful anti-oxidant, immunomodulator and growth stimulator 4/ C.Power is highly soluble in most organic solvents resulting in maximal absorption. 5/ C.Power possesses outstanding thermal stability Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  22. C.Power  Worlds most availableVitamin C PEG-ylatedVitamin C Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  23. C.Power  Worlds most availableVitamin C Molecular structure of 3-Pegylated-Asc.acid Long acting Non-ionic Liquid Long acting form Organic soluble High stability High absorption Safety Increased Lipophilicity enzymatic hydrolysis Increased Stability Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  24. C.Power  Worlds most availableVitamin C Stability Data of 3-Pegylated-Ascorbic Acid Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  25. C.Power  Worlds most availableVitamin C Stability comparison of different forms of Vit.C Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  26. C.Power  Worlds most availableVitamin C Efficacy comparison Vit C vs C.Power Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  27. C.Power  Worlds most availableVitamin C Efficiency as a feed additive Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  28. C.Power  Worlds most availableVitamin C Economical value of C.Power • Increased absorbency 6 times • 2. Heat-, acid- and mineral resistance 10 times • 3. Immunogenicity NEW • 4. Vitamin-C was almost unable to use as feed additive before C.Power NEW • 5. No pollution problems as there are no phosphate inside of C.Power NEW • 6. Unique and patented product NEW • 7. Differentiation of finished product NEW • Total Economical Value of C.POWER60 times +  Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  29. C.Power  Worlds most availableVitamin C Laboratory trial data - broilers Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  30. C.Power  Worlds most availableVitamin C Experimental Design – 1/2 Study Animals: ROSS308 broilers 3300 birds average age at start: 4 days Study Material: DSM ROVIMIX C-EC, ethylcellulose-film coated VitaminC MERC C.POWER, pegylated VitaminC Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  31. C.Power  Worlds most availableVitamin C Experimental Design – SetUp Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  32. C.Power  Worlds most availableVitamin C Experimental Design – Impact on growth and Mortality Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  33. C.Power  Worlds most availableVitamin C Experimental Design – Impact on Plasma & Liver levels Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  34. C.Power  Worlds most availableVitamin C Experimental Design – Impact on Immunity part 1 Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  35. C.Power  Worlds most availableVitamin C Experimental Design – Impact on Immunity part 2 Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  36. C.Power  Worlds most availableVitamin C Experimental Design – Impact on stress level Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  37. C.Power  Worlds most availableVitamin C FIELD TRIAL DATA • Layers • Broilers Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  38. C.Power  LAYER 1 Worlds most availableVitamin C  Feeding : C.Power 100ppm (100g/MT of feed) Results : Improving egg shell quality Decreasing broken egg production Egg shell thickness : Increase 8.6% in average (0.386mm → 0.416mm) * Average Temperature on August is around 30~35℃. Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  39. C.Power  BROILER 1 Worlds most availableVitamin C • Trial date : 13july-21aug. • Average Temperature on August is around 30 ~ 35℃. • Feeding : C.Power 100ppm (100g/MT of feed) • Results : Improving FCR, Uniformity and Growth • Decreasing Mortality and Heat stress * Average Temperature on August is around 30~35℃. Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  40. C.Power  BROILER Worlds most availableVitamin C Pictures at 30days Treated flock ( 100ppm C.Power during the 6 hot weeks of summer) shows better uniformity, absence of hypoglycemia and respiratory disease control treated Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  41. C.Power  Worlds most availableVitamin C BROILER Summarry and conclusions Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  42. C.Power  BROILER 2 Worlds most availableVitamin C • Trial date : 27July. ~ 31August at YDK farm. • Feeding : C.Power at 100ppm for 3days from day16 till day18 . • Farm management program is as follows * Average Temperature on August is around 30~35℃. Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  43. C.Power  BROILER 2 Worlds most availableVitamin C • IBD outbreak from day20day to day25. • Net decrease of mortality in treated group, 3200 dead birds in control • vs 730 dead birds in treated group over 1 week time. • This is a decrease in mortality of 78% !! • Trial date : 27July. ~ 31August at YDK farm. • Feeding : C.Power at 100ppm for 3days from day16 till day18 . • Farm management program is as follows

  44. C.Power  BROILER 2 Worlds most availableVitamin C Supplementation of C.Power at 100ppm during 3 days IBD infection Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  45. C.Power  BREEDERS, impact of C.POWER on production (1/4) Batch 1 – Hubard GP – C.Power during 10 weeks (25-35) Worlds most availableVitamin C Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  46. C.Power  BREEDERS, impact of C.POWER on production (1/4) Batch 1 – Hubard GP – C.Power during 10 weeks (25-35) Worlds most availableVitamin C Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  47. C.Power  BREEDERS, impact of C.POWER on production (2/4) Worlds most availableVitamin C Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  48. C.Power  Worlds most availableVitamin C BREEDERS, impact of C.POWER on production (3/4) Batch 2 – Hubard GP – C.Power during 10 weeks Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  49. C.Power  BREEDERS, impact of C.POWER on production (3/4) Batch 2 – Hubard GP Worlds most availableVitamin C Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

  50. C.Power  BREEDERS, impact of C.POWER on production (4/4) Batch 2 – Hubard GP Worlds most availableVitamin C End of treatment week 35 Mercordi BVBA Stadsbeemd 1215 – B-3545 Halen www.mercordi.com

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