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Clinical Implications of Group B Streptococcus in Ascites Fluid

Explore the prevalence, risk factors, and clinical implications of Group B Streptococcus in peritonitis cases, with focus on associated conditions and severity of the disease. Learn about manifestations, pathophysiology, and secondary bacteremia.

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Clinical Implications of Group B Streptococcus in Ascites Fluid

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  1. Fascinoma RoundsGroup B streptococcus in ascitic fluid October 26th, 2005 Sharmistha Mishra, Vanessa Allen, And with great thanks to Subash Mohan

  2. Case #3: Group B streptococcus in ascitic fluid • How common is GBS in peritonitis? • What are the clinical implications of GBS peritonitis?

  3. Risk Factors • Cases associated with continuous ambulatory peritoneal dialysis (CAPD) • Colonization of genital and anal tract • Seven cases have been described previously and all had a very severe course Liakopoulos V. et al. Clinical Nephrology. 62(5):391-6, 2004 Nov. Scanziani R. et al. Nephrology Dialysis Transplantation. 14(9):2222-4, 1999 Sep.

  4. Group B Strep Infection • Seen in neonates and peripartum women • In non -pregnant adults (2/3rds of cases) • DM, Liver failure, RF, malignancy, AIDS • Most often manifested as • skin or soft-tissue infection • bacteremia • genitourinary infection • Pneumonia • Peritonitis • 5-10% caused by strep spp. • Most common is viridans streptococcus

  5. Pathophysiology • From GU source • 10- 30% of pregnant women colonized • Peritonitis secondary • Severity of disease • Secondary bacteremia Farley MM, et al. N Engl J Med. 1993;328:1807-1811.

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