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PARP-1, PARP-2 and XRCC1 in SSBR and BER: a contemporary model

XRCC1. g -Rays. APE1. 5'. 5'. P. OH. P. OH. 5'. 5'. P. OH. XRCC1 is an essential scaffold protein that interacts sequentially with various actors of the BER / SSBR pathways. PARP-1. PARP-1. XRCC1. Lig3. PARP-2. OH. P. Lig3. Polß. PARP-1. APTX. PNK. XRCC 1. Lig3. NLS.

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PARP-1, PARP-2 and XRCC1 in SSBR and BER: a contemporary model

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  1. XRCC1 g-Rays APE1 5' 5' P OH P OH 5' 5' P OH XRCC1 is an essential scaffold protein that interacts sequentially with various actors of the BER / SSBR pathways PARP-1 PARP-1 XRCC1 Lig3 PARP-2 OH P Lig3 Polß PARP-1 APTX PNK XRCC1 Lig3 NLS PARP-1 BRCT 2 BRCT 1 E D 1 183 314 371 538 633 PNK FEN1 PARP-1 Polß PNK PARP-2 hOGG1 APE1 TdP1 XRCC1 Lig3 PCNA PARP-2 PARP-1 Polß PARP-1, PARP-2 and XRCC1 in SSBR and BER: a contemporary model Base damagerecognition SSB detection SSB signallingXRCC1 recruitment End processing Gap filling Lig3 XRCC1 Huber et al. 2004, DNA Repair, 3, 1104 DNA ligation

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