1 / 53

Chapter 4

Chapter 4. Alcohol and Inhalants of Abuse. Preview. We will discus the phamacokinetics and phamacodynamics of alcohol How there is tolerance and cross tolerance of alcohol Why there is a Psychological dependence for chronic users What treatment for alcohol dependance. Preview .

xantara
Download Presentation

Chapter 4

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Chapter 4 Alcohol and Inhalants of Abuse

  2. Preview • We will discus the phamacokinetics and phamacodynamics of alcohol • How there is tolerance and cross tolerance of alcohol • Why there is a Psychological dependence for chronic users • What treatment for alcohol dependance

  3. Preview • What are inhalants • Why are they abused • What are the effects of inhalants • What are some treatments

  4. What is Alcohol? • Alcohol is a sedative • It’s is primarily used for recreation not medicine • 2nd Largest used psychoactive drug in the world (first is caffeine)

  5. Alcohol’s chemical composition CH3 CH2OH Yellow – H Black – C Red – O

  6. The Phamacokinetics of Alcohol - Absorption • Alcohol is both soluble in fat and water • This means alcohol is absorbed though the gastrointestinal tract and through the Blood Brain barrier • 20% is absorbed through the stomach the other 80% through the upper intestine

  7. The Phamacokinetics of Alcohol - Distribution • Alcohol easily crosses the Blood-Brain barrier because it is lipid soluble • Alcohol can even cross the placental barrier where there can be an occurrence of fetal alcohol syndrome (FAS). FAS occurs in 30% to 50% of all alcoholic mothers

  8. The Phamacokinetics of Alcohol – Metabolism and Excrection • 95% of all alcohol is digested (metabolized) by an enzyme called alcohol dehydrogenase • 85% via the liver • 15% via the stomach – a full stomach can metabolize more • Alcohol is exposed to first-pass metabolism • 5% is excreted via the lungs

  9. Metabolism of Alcohol by Men and Women • Since men have naturally less fat then woman and bigger blood vesicles, men have a lower Blood Alcohol Concentration (BAC) then woman • Also, woman have 50% less enzyme then men, thus the metabolism rate is slower • Remember – Alcohol metabolism is zero order

  10. 10 Non-alcoholic Women 10 Alcoholic Women Intravenous Oral 300 300 Blood ethanol concentrations (mM) 10 10 Non-alcoholic Men Alcoholic Men 300 300 Time after ethanol administration (minutes)

  11. How the Liver Metabolizes Alcohol • 1. NAD+ + Ethanol NADH + Acetaldehyde Enzyme: Alcohol Dehydrogenase • 2. NAD+ + Acetaldehyde NADH + Acetic acid Enzyme: AldehydeDehydrogenase • 3. Acetic acid  Water + CO2 Uses ATP ATP  AMP • Disulfiram inhibits AldehydeDehydrogenase • Step 2 is the rate limiting step

  12. More on Metabolism • BAC is measured in grams of alcohol per liter • .08 is the legal limit in New York • An average person can metabolize 8 to 10 milliliters of pure alcohol per hour • More than that, BAC increases • Weight is a big determiner in the concentration of alcohol

  13. Phamacodynamics of Alcohol • Suppresses Calcium-ion Currents • Alterates of cAMP and the Sodium-Pumps • Also effects Glutamate systems (excitatory) and GABA Systems (inhibitory) • Effects Serotonin and Dopamine Systems

  14. Glutamate Receptors • Inhibitor of NMDA-subtype of Glutamate Receptors • Depresses responsiveness of NMDA receptors • Acoamprosate an anti-craving drug to alcohol interacts with NMDA receptors • Glutamate Antagonist

  15. GABA Receptors • Ethanol is a GABA agonist, binds to a subunit of the GABAA receptor • It increases Cl- ions thus hyperpolarizing the cell • Low doses of alcohol can reduce panic and anxiety

  16. Other pharmacodynamic effects • Chronic use of Alcohol changes mRNA of the Neuron • As a result, Ach, DA, opioid and serotnin systems are effected • Abuse potential maybe due to increase in dopamine

  17. Pharmacological Effects • Alcohol effects many different functions of the brain • Alertness, motor functions, and intellectual abilities decrease • Combined with other sedatives (benzodiapines), this increase the sedativeness of alcohol

  18. Pharmacological Effects – Cont. • Alcohol dilates blood vessels, thus releasing more body heat and decreasing blood temp. • Large doses of Alcohol increases the risk of heart failure • Small Doses decrease the risk of coronary disease • Alcohol is a diuretic – it decrease the amount of diuretic hormone thus increasing the excretion of water

  19. Psychological Effects • Low amounts of Alcohol have minimal Change in behavior < .04 BAC • From .04 - .10 BAC, your 4x more likely to get into an accident • .12-.18 Likelihood increases to 25x • .23-.29 your in a stupor • .30 - .33 your in a coma • .39 and greater, your dead

  20. Psychological Effects – Cont. • 50% of all highway crimes and accidents are alcohol related

  21. Health Effects • Alcohol is highly caloric but has little nutritional value • Vitamin and trace element deficiencies are linked to alcohol • Liver and stomach cancers

  22. Tolerance • Metabolic Tolerance – Increase of alcohol digesting enzyme by the liver • Behavioral Tolerance – Brain adapts to amount of drug present. A tolerant person can have a BAC 2x the amount of a nontolerant and act the same • Environmental – the same environment over time when drinking increases tolerance. Changing the environment decrease tolerance

  23. Dependence • Many be do to either increase in dopamine and/or the effect of decreased anxiety • Withdrawal and alcohol seizures may occur in 10% of people who stop taking alcohol • This is due to the neuron producing more glutamate to counteract the effects of increased GABA • When GABA leaves, there is an overabundance of glutamate, thus causing a seizure

  24. Dependence – Cont. • Other effect of withdrawal include hallucinations, psychomotor, agitation, confusion • This syndrome is also known as delirium tremens (DT)

  25. Side effects and Toxicity • Liver damage – 75% of all deaths due to alcoholism are caused by cirrhosis of the liver, the 7th most common cause of death in the US • Other effects are Panreatitis and chronic gastritis causing peptic ulcers

  26. Side effects and Toxicity – Cont. • The metabolizing of alcohol produces free radicals, causing cancer in the liver and some hypothesis breast cancer also • Alcohol has immunosuppressive effects thus promoting tumor growth

  27. Teratogenic Effects • FAS – Fetal Alcohol Syndrome is accountable for 3 to 5 birth defects in 1000 • Causes low intelligence, mental retardation, behavioral abnormalities • There is retard body growth • Facial Abnormailities

  28. Teratogenic Effects – Cont. • Adolescents engage in anti-social behavior • These people are slow learners • Congenital heart defects • The point is – drinking is bad if you are pregnant, do not do it.

  29. Alcoholism & It’s Pharmacological Treatment • 1950s : American Medical Association recognized the syndrome of alcoholism as an “ILLNESS” • Ø1970s : Alcoholism redefined as a “CHRONIC, PROGRESSIVE, AND POTENTIALLY FATAL DISEASE.”

  30. Alcoholism & It’s Pharmacological Treatment – Cont. • 1992: Alcoholism is characterized by impaired control over drinking, preoccupation w/the drug “alcohol”, use of alcohol despite adverse consequences ( impairments in such areas as physical health, psychological functioning, interpersonal functioning, and occupational functioning, as well as legal financial, and spiritual problems) , and distortions in thinking, most notable DENIAL!

  31. Alcoholism & It’s Pharmacological Treatment – Cont. • Denial is nearly always the major obstacle (integral part) • Environmental Factors seem to be less important than Genetic Factors • Alcoholism is used as a “self-medication” of psychological distress.

  32. Alcoholism & It’s Pharmacological Treatment – Cont. • Often times alcoholism is associated with addiction to other drugs, depression, manic-depressive illness, anxiety disorder, or antisocial personality • 30-50% meet criteria for major depression

  33. Alcoholism & It’s Pharmacological Treatment – Cont. • 33% have a coexisting anxiety disorder • many have anti-social personalities • some are schizophrenic • 36% are addicted to other drugs • 14 million Americans have serious alcohol problems. 7 million considered Alcoholics • 100,000 Americans die each year of alcoholism

  34. Pharmacotherapies for Alcoholic Abuse & Dependence: • Eliminating the taking of alcohol is an obvious therapeutic strategy • Vaillant 60 has proven POOR long-term outlook of alcoholism treatment (both pharmacologic or behavioral)

  35. Goals of Pharmacotherapy for Alcohol Dependence & Abuse • Reversal of the severe pharmacological effects of alcohol • Treatment & prevention of withdrawal symptoms & complications • Maintaining abstinence & preventing relapse by : -using agents that decrease craving for alcohol -stop the loss of control over drinking -make it unpleasant to ingest alcohol

  36. Goals of Pharmacotherapy for Alcohol Dependence & Abuse – Cont. • Treatment of coexisting psychiatric disorders that complicate recovery Note: • No agent can reverse the acute pharmacologic effects of alcohol • Pharmacotherapies are available for the treatment & prevention of withdrawal symptoms & complications in alcohol-dependent people who are decreasing or discontinuing alcohol

  37. Pharmacotherapies for Alcohol Withdrawal • Benzodiazepines are the drug of choice for acute alcohol withdrawal • Improve symptoms • Prevent seizures & DTs • Substituting this long-acting drug prevents or suppresses w/drawal symptoms

  38. Pharmacotherapies for Alcohol Withdrawal – Cont. • The “longer-acting” benzodiazepine is either: • 1. Maintained at a level low enough to allow the person to function • 2. Or is withdrawn gradually

  39. Drugs to Help Maintain Abstinence • Alcohol-sensitizing drugs(including: disulfiram & calcium carbimide) : • Used to prevent the patient from drinking by producing an aversive reaction when consuming alcohol • The drug alters the metabolism of alcohol

  40. Drugs to Help Maintain Abstinence – Cont. -Allows acetaldehyde to accumulate which in turncauses acetaldehyde syndrome (characterized by throbbing headache, nausea, vomiting, chest pain ect.)

  41. Drugs to Help Maintain Abstinence – Cont. • Opioid Antagonist including: Naltrexone, Nalmefene, Acamprosate are used in European Countries • Naltrexone: • Used to reduce craving for alcohol • The hypothesis is that the reinforcing properties of alcohol involve the opioid system

  42. Drugs to Help Maintain Abstinence – Cont. - The blockade of the system by use of naltrexone should reduce cravings by reducing the positive reinforcement associated w/ alcohol use

  43. Drugs to Help Maintain Abstinence – Cont. • Dopaminergic drugs: use in maintaining abstinence • Positive reinforcement associated w/ alcohol attractiveness appears to involve the dopaminergic reward system • Withdrawal may be accompanied by hypofunction of this reward system

  44. Drugs to Help Maintain Abstinence – Cont. - Depression is often comorbid (<coexisting) w/ alcohol dependency & some dopaminergic drugs have antidepressant results.

  45. Drugs to Help Maintain Abstinence – Cont. • Serotoninergic Drugs (used to treat alcohol dependence) -Serotonin-specific reuptake inhibitors (SSRIs) (e.g. fluoxetine) : used for treating depression & anxiety. - Serotonin 5-HT1a agonist (e.g. buspirone): used for treating anxiety. Effective in treating comorbid anxiety in alcoholics but less effective at reducing alcohol consumption.

  46. Drugs to Help Maintain Abstinence – Cont. • Serotonin 5-HT3 antagonist (e.g. ondansetron) : used for treating nausea.

  47. INHALANTS OF ABUSE • Inhalant abuse is the intentional inhalation of a volatile substance for the purpose of achieving a euphoric state • Consist of chemicals that are volatile at room temperature. Inhaled substances include: Anesthetics (nitrous oxide),Household Solvents (paint thinners),Art & office supplies (markers),Household gas products (propane tanks),Household aerosol propellants (hair spray),Aliphatic nitrites & Organic Solvents (amyl nitrite capsules)

  48. Why are inhalants use and who abuses them • In rate studies, low concentrations of vapor increased motor activity and self-stimulation in the lateral hypothalamus • Increased vapor concentrations suppressed the activation of the brain reward systems & also brought on behavioral depression • Peak inhalant abuse age is 14-15 years old • Some as young as 6-8 years old

  49. Why are inhalants use and who abuses them – Cont. • Often injuries are associated with frequent use but there are instances of “Sudden Sniffing Death Syndrome” that can occur to first time users • 20% of youths have experienced inhalant abuse by the end of 8th grade.

  50. ACUTE INTOXICATION & CHRONIC EFFECTS • Inhaled vapors produce rapid onset of a state of intoxication (similar to alcohol intoxication), sedation with anxiolysis, disinhibition, drowsiness, light-headedness, & euphoria. • Increased intoxication, the user experiences ataxia (staggering), dizziness, delirium, & disorientation.

More Related