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New Product Anouncement Cephalosporinase - Plates

New Product Anouncement Cephalosporinase - Plates. Requirements for Plates ! . Inactivation of a broad spectrum of cephalosporins Inactivation of residuals of disinfectants (especially contact plates). ß-Lactam-Antibiotics. Penicillins Ampicillin, Mezlocillin, Penicillin

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New Product Anouncement Cephalosporinase - Plates

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  1. New Product Anouncement Cephalosporinase - Plates

  2. Requirements for Plates ! • Inactivation of a broad spectrum of cephalosporins • Inactivation of residuals of disinfectants (especially contact plates)

  3. ß-Lactam-Antibiotics • Penicillins Ampicillin, Mezlocillin, Penicillin • 1st Generation Cephalosporins: Cefazolin, Cefalotin, Cefalexim • 2nd Generation Cephalosporins: Cefamandol, Cefuroxim, Cefoxitin (Cefomycin or Methoxa-Cephalosporine) • 3rd Generation Cephalosporins: Cefotaxim, Ceftriaxon (Rocephin), Ceftazidim • 4th Generation Cephalosporins: • Cefquinom, Cefepim • Carbapenems: Meropenem, Imipenem, Ertapenem

  4. Activity of ß-Lactamase I • ß-Lactamase I (= Penicillinase or Penase) hydrolyses the ß-Lactam ring of Penicillins • Definition - Activity of Penicillinase: 1 Unit = Cleavage of 1 Micromol Penicillin G per minute at pH 7 and 25°C

  5. Activity of ß-Lactamase II • ß-Lactamase II (= Cephalosporinase or Cephase) hydrolyses the ß-lactam ring of Cephalosporins • Definition - Activity of ß-Lactamase II: 1 Unit = Cleavage of 1 Micromol Cephalosporin C per minute at pH 7 and 25°C

  6. Activity of different ß-Lactamase II Media - Tests using antibiotic discs -

  7. Activity of different ß-Lactamase II Media - Tests using anitbiotic discs -

  8. Summary of spectrum of efficacy for TSA Contact +LT +ß-Lactamase II (Article number 825) • Good inactivation in antibiotic disc experiments: • Cefixim 5 µg /disc • Cefazolin 30 µg /disc • Meropenem 10 µg /disc • Cefotaxim 30 µg /disc • Ceftriaxon 30 µg /disc • Imipenem 10 µg /disc • Moderate inactivation in antibiotic disc experiments: • Cefuroxim 30 µg /disc • Cefquinom 10 µg /disc • Poor or missing inactivation in antibiotic disc experiments: • Cefepim 30 µg /disc • Cefoxitin 30 µg /disc

  9. Developement of new Cephalosporinase with a broad inactivation spectrum LACTAMATORTM

  10. Inactivating Properties of Different ß-Lactamase II Media - Tests using Antibiotic Discs and S. aureus -

  11. Inactivating Properties of Different ß-Lactamase II Media - Tests using Antibiotic Discs and K. rhizophila -

  12. Summary of spectrum of efficacy for TSA Contact +LT +Cephase ICR+ (Article number 823) Good inactivation of the following antibiotics: • Penicillins: • Ampicillin 25 µg, Mezlocillin 30 µg, Penicillin 10 µg • Cephalosporins 1st generation: • Cefazolin 30 µg /disc • Cephalosporins 2nd generation: • Cefuroxim 30 µg, Cefoxitin 30 µg (Cephamycin) • Cephalosporins 3rd generation: • Cefotaxim 30 µg, Ceftriaxon 30 µg • Cephalosporins 4th generation: • Cefepim 30 µg, Cefquinom 10 µg • Carbapenems: • Ertapenem 10 µg, Imipenem, 10 µg, Meropenem 10 µg

  13. New Products • TSA Contact +LT + Cephase – ICR+ - article number 823 Product available for advance orders shelf life of 4 months completed in June 2009 • TSA +LT + Cephase – ICR – article number 03085e Product available for advance orders shelf life of 4 months completed end of July 2009 • LACTAMATORTM LCT-5 • (10 vials each with 50 IU Cephalosporinase and 500 IU Penicillinase, lyophilised) Product available in April 2009 • LACTAMATORTM LCT-20 • (1 vial with 2 kIU Cephalosporinase and 20 kIU Penicillinase, lyophilised) Product available in April 2009

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