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Etiologic Factors

Etiologic Factors. Chemical carcinogen Aflatoxin B1: Most potent, ubiquitous, natural chemical carcinogen from Aspergillus fungus Pyrrollizidine alkaloids Tannic acid safrole Hepatits HBsAg : a hepatitis B antigen Hepatitis C Risk Factors. Risk Factors. Unusual:

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Etiologic Factors

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  1. Etiologic Factors • Chemical carcinogen • Aflatoxin B1: • Most potent, ubiquitous, natural chemical carcinogen • from Aspergillusfungus • Pyrrollizidine alkaloids • Tannic acid • safrole • Hepatits • HBsAg: a hepatitis B antigen • Hepatitis C • Risk Factors

  2. Risk Factors • Unusual: • primary biliary cirrhosis • Hemochromatosis • α1 Antitrypsin deficiency • glycogen storage disease • citrullinemia • porphyriacutaneatarda • hereditary tyrosinemia • wilson’s disease • Common: • Cirrhosis from any cause • Hepatitis B or C • Chronic ethanol • consumption • Nonalcoholic steotoheptitis (NASH) • Aflatoxin B1 or mycotoxins

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