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Molecular basis for the action of Au(I) drugs in rheumatoid arthritis

Molecular basis for the action of Au(I) drugs in rheumatoid arthritis. chronic inflammatory disease. Rheumatoid arthritis. immune system attacks joints. Wikipedia - Joint , Rheumatoid Arthritis. Anti-inflammatory and immunomodulatory effects of gold(I)-containing drugs. Collagenase.

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Molecular basis for the action of Au(I) drugs in rheumatoid arthritis

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  1. Molecular basis for the action of Au(I) drugs in rheumatoid arthritis

  2. chronic inflammatory disease Rheumatoid arthritis immune system attacks joints Wikipedia - Joint , Rheumatoid Arthritis

  3. Anti-inflammatory and immunomodulatory effects of gold(I)-containing drugs Collagenase genes involved in promoting inflammation down-regulated proteins involved in promoting inflammation Cytokines interleukin- 2 (IL-2) interleukin-2 receptor J. Biol. Chem., Vol. 276, Issue 36, 34074-34081, September 7, 2001

  4. Anti-inflammatory and immunomodulatory effects of gold(I)-containing drugs antioxidative stress genes GO induce antioxidative stress proteins heme oxygenase g - glutamylcysteine synthetase J. Biol. Chem., Vol. 276, Issue 36, 34074-34081, September 7, 2001

  5. Transcription factors facilitate or inhibit gene expression RNA Polymerase II c-Jun c-Fos TGACTCA DNA Regulatory Region Gene Transcription AP-1 transcription factor http://www.piercenet.com/Proteomics/browse.cfm?fldID=843944B3-65F9-42A9-BF7A-6F91B4A6FBBB http://en.wikipedia.org/wiki/Transcription_factor http://www.ndsu.edu/instruct/mcclean/plsc731/transcript/transcript1.htm

  6. Gold(I)-drugs inhibit AP-1

  7. Electrophoresis Gel Electrophoresis EMSA Lane 1 is a negative control, and contains only DNA. Lane 2 contains protein as well as a DNA fragment that, based on its sequence, does not interact. Lane 3 contains protein and a DNA fragment that does react; the resulting complex is larger, heavier, and slower-moving. Electrophoretic Mobility Shift Assay

  8. Gold(I)-drugs inhibit AP-1 binding to DNA Proc. Natl. Acad. Sci. USA Vol. 92, pp. 4497-4501, May 1995

  9. Effect of Gold(I)-drugs on other transcription factors Proc. Natl. Acad. Sci. USA Vol. 92, pp. 4497-4501, May 1995

  10. Gold(I) inhibition of transcription in vivo RNA Polymerase II c-Jun c-Fos TGACTCA DNA Regulatory Region Gene for CAT Transcription AP-1 transcription factor (CAT) chloramphenicol acetyltransferase reporter gene

  11. Interaction of Cys residues on Jun and Fos with Au(I) ~CH2SH ~CH2OH Proc. Natl. Acad. Sci. USA Vol. 92, pp. 4497-4501, May 1995

  12. AP-1 : DNA interaction Nature vol. 373, pp.257-261, 1995

  13. AP-1 : DNA interaction Nature vol. 373, pp.257-261, 1995

  14. AP-1 : DNA interaction Nature vol. 373, pp.257-261, 1995

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