U.S. ARMY MEDICAL RESEARCH & MATERIEL COMMAND MG George Weightman - Commanding

1. U.S. ARMY MEDICAL RESEARCH & MATERIEL COMMANDMG George Weightman - Commanding Telemedicine and Advanced Technology Research Center… Fulfilling The Vision Thru R&D USAMRMC & TATRC Overview Colonel Karl Friedl, Director, Telemedicine & Advanced Technology Research Center (TATRC) Heather White, DoD Research Specialist, Office of Sponsored Programs

2. Agenda • Command Structure/Organization • TATRC Background and Mission • Funding Mechanisms • Research Areas of Interest • Other Collaborative Opportunities • Closing

3. Medical Research and Materiel Command OverviewMission and Vision MISSION VISION Provide medical knowledge and materiel lifecycle management to protect, treat and optimize warfighter health and performance across the full spectrum of operations. We are the world’s experts and leaders in the military relevant biomedical research and medical materiel communities, delivering the best medical solutions to enhance, protect, treat, and heal our warfighters.

4. U.S. ARMY MEDICAL DEPARTMENT ORGANIZATION CHART MEDICAL COMMAND (MEDCOM) OFFICE OF THE SURGEON GENERAL MEDICAL RESEARCH & MATERIEL COMMAND (USAMRMC) AMEDD CENTER & SCHOOL REGIONAL MEDICAL COMMANDS DENTAL COMMAND (DENCOM) VETERINARY COMMAND (VETCOM) CHPPM* MG Weightman CG, USAMRMC *Center for Health Promotion and Preventive Medicine

5. Command Relationships & Personnel USAMRMC TATRC USAMRMC Actual Personnel – Sep 2008 HEADQUARTERS CDMRP USAARL USAISR USAMRICD USAMRIID USARIEM WRAIR USAMMDA USAMMA USAMMCE USAMITC USAHFPA USAMRAA Medical IM/IT Health Facilities Procure-ment Support Medical Logistics Medical Advanced Development Medical Research & Technology

6. Core Medical S&T Program Areas • Military Infectious Diseases • Medical readiness • Vaccines • Biotechnology • Prophylaxis/treatment drugs • Diagnostics/prognostics • Vector control • Clinical Rehabilitative Medicine • Prosthetics • Regenerative Medicine • Clinical Studies • Ocular and Auditory Rehabilitation & Repair • Combat Casualty Care • Lightweight medicalequipment • Medical C4ISR • Trauma care • Health monitoring and diagnostic technology • Military Operational Medicine • Soldier selectionand sustainment • Soldier performance • Warrior system modeling • Health hazards protection • Diagnostics/prognostics • Health monitoring • Intramurally funded • Management costs from President’s Budget • 88% of S&T budget goes to in-house DOD labs ; The S&T objectives are placed into the POM cycle budget request (5-7 years out)

7. Telemedicine and Advance Technology Research Center Mission Explore science and engineering technologies ahead of programmed research, leveraging other programs to maximize benefits to military medicine Vision Be the government model of opportunity-driven research agility

8. Evolution of TATRC DIN/PACS and Teleradiology Filmless Hospital First Decade Telemedicine and e-health Establishment of Gap Funding Second Decade Present • Innovation in Managing Technology Ability to Harness • Academic innovation • Congressional interests • Industrial investment • Aligning CSIs to the Larger Army Medical Research Objectives • Facilitate Innovations for the Command • Spearhead Collaboration Across Agencies

9. TATRC…….. • Element of HQ, USAMRMC • Shapes Congressional Special Interest projects to DoD relevance • Leads DoD research in e-Health (computational biology & clinical informatics) • Bridges military medical research gaps & promotes innovative pilot research • Manages large cutting edge R&D programs • 15 Core Research Portfolios • > 800 active projects • SBIR/Gap funds management • 16-20% - Withhold • DHP, Economic improvement, SBIR/STTR, MRMC, TATRC TATRC FUNDING HISTORY - Since FY98, $2.10B managed R&D projects Congressional Special Appropriations – RDT&E

10. Research Portfolios Current Staff 6 Military Officers 8 Civilians 54 IPAs (includes 10 part time) 88 Contractors 5 Consultants Coordinating Partnerships RAD I: Infectious Disease RAD II: Combat Casualty Care RAD III: Operational Medicine RAD IV: Clinical Rehab Medicine Key Product Lines Simulation and Training Technology Mr. Gene Wiehagen Medical Robotics Dr. Gary Gilbert Health Information Technologies CDR Stephen Steffenson Medical Imaging Technologies Dr. Anthony Pacifico Advanced Prosthetics and Human Performance Mr. Troy Turner Computational Biology Dr. Jacques Reifman Biomonitoring Technologies Dr. Eva Lai BHSAI BIC New Initiatives & Basic Science Neuroscience Dr. Ken Curley Genomics/ Proteomics Dr. Anne Westbrook Integrative Medicine Dr. Jean Louis Belard Regenerative Medicine Dr. Eva Lai Nano-Medicine and Biomaterials Dr. Warren Grundfest Medical Logistics Mr. John DePasquale Acoustic Trauma Dr. Michael Holtel Human Performance Optimization Dr. Sylvain Cardin Trauma Dr. Tim Broderick Neuro- Rehabilitation MAJ Teresa Brininger Infectious Disease Ms. Amber Stanley

11. Research & Development Strategies High Risk, High Payoff New Ideas, Knowledge Link to the Warfighter DARPA Stryker Brigade – Deployed Forces Academia Academia + Government + Industry (Maximum Bang for Buck) Innovation, Transition Expanded Resource Base International Coalitions Industry Service Labs Interagency Partners

12. www.tatrc.org

13. Funding Opportunities USAMRMC BAA 08-1The USAMRMC Broad Agency Announcement (BAA) 08-1 is intended to solicit research ideas that work towards providing solutions to medical problems of importance to the American warfighter at home and abroad. SBIR/STTRSmall Business Innovative Research (SBIR) and Small Business Technology Transfer (STTR) are highly competitive programs designed to allow small businesses to harness their innovative talents, with the incentive to profit from commercialization. AMEDD Advanced Medical Technology Initiative (AAMTI)The U.S. Army Medical Research and Materiel Command's (USAMRMC) mission is to provide solutions to medical problems of importance to the American war fighter at home and abroad. The AMEDD Advanced Medical Technology Initiative (AAMTI) plays a vital role in the fulfillment of these objectives.

14. USAMRMC Broad Agency Announcement (BAA) 08-1 • *Provides a general description of USAMRMC’s research programs • Specific areas of interest • General information • Evaluation and selection criteria • Proposal preparation instructions • *BAA is continuously open, 24/7 • *Accepts proposals on a rolling basis. • *Pre-proposals may be submitted and will be evaluated at any time • throughout the year.

15. Research Areas of Interest • Military Infectious Diseases Research Program • Combat Casualty Care Research Program • Military Operational Medicine Research Program • Medical Biological Defense Research Program • Medical Chemical Defense Research Program • Telemedicine and Advanced Technology Program • Special Programs

16. Military Infectious Diseases Research Program • Vaccines (characterization, development, pathology) • Antiparasitic Drugs (discovery, design, & development) • Vector Development (arthropod vectors & vector-borne diseases) • Therapeutic drug development (screen, synthesize, and develop)

17. Combat Casualty Care Research Program • Stop blood loss • Limit the immediate, short- and long-term deleterious consequences of severe hemorrhage • Non/Minimally invasive sensors to detect and warn of impending vascular collapse • Improved preservation, storage, transportability, and processing of red blood cells, platelets, and plasma • Traumatic Brain Injury • Non/Minimally invasive sensors or assays to rapidly diagnose the severity of brain injury • Drugs, biologics, or other agents to mitigate post-injury affects • Secondary Damage to Organs • Additional Aspects of Casualty Care

18. Military Operational Medicine Research Program • Injury Prevention and Reduction • Psychological Health and Resilience • Environmental Health and Protection • Physiological Health • Medical Biological Defense Research Program • Viral, Toxin and Bacterial Studies • Drug Development • Development, synthesis and testing of compounds that possess antiviral, antibacterial, immunomodulatory or antitoxin activities • Identification and Diagnosis of antigens and antibodies

19. Medical Chemical Defense Research Program • Maintain the Technologic Capability to meet present requirements and counter future chemical warfare agent threats. • Provide Medical Countermeasures for the individual soldier to maintain combat effectiveness and prevent or reduce injury from chemical warfare agents. • Provide Medical Management of Chemical Casualties to enhance survival and expedite the return-to-duty of chemical warfare agent casualties through definitive therapies and life support technologies.

20. Telemedicine & Advanced Technology Program • Medical Robotics – to treat patients in fixed and mobile medical facilities • Health Information Technologies • Medical Imaging Technologies – portable, high performance, decision support, advanced surgical cameras • Advanced Prosthetics & Human Performance • Computational Biology - analysis, interpretation, prediction, and modeling of biological data • Biomonitoring Technologies - remote and wireless • Simulation and Training Technology • Genomics and Proteomics - signatures and markers • Chronic Disease Management

21. Telemedicine Cont. • Infectious Disease - vaccines, therapeutic agents, diagnosis, vector control, wound infections, and sepsis • Neuroscience - training, treatment, prevention, protection, assessment, and diagnosis. • Regenerative Medicine – development of treatments for damaged/non-functional tissues and organs • Nanomedicine and Biomaterials – identify novel developments in materials science and biomaterials leading to new drug s and improved devices • Trauma - develop materials, therapies, treatments, and diagnostics that will improve trauma treatment • Medical Logistics – transformational technologies applied to core logistics systems, focusing on devices, practices, and business processes to improve military medical logistics.

22. Small Business Innovative Research (SBIR) & Small Business Technology Transfer (STTR) *Eligible companies submit proposals against a specific topic, which is prepared by a DoD subject-matter expert *Three Phase Process Phase I -startup phase, with awards up to $100,000 Phase II - up to $750,000,expand on Phase I results and explore commercialization potential Phase III - laboratory to the marketplace, no funds available for support *Solicitations are released only at specific times during the year. For more information: Small Business Administration’s (SBA) http://www.sbaonline.sba.gov/SBIR/indexsbir-sttr.html#sttr DoD SBIR/STTR program http://www.acq.osd.mil/osbp/sbir/overview/index.htm

23. AMEDD Advanced Medical Technology Initiative (AAMTI) • AAMTI is an OTSG-funded program initiated in 1999. Each FY $5,000,000 in P8 funds are MIPRed/FADed to AMEDD facilities to enable technology demonstrations. • The key objectives of the AAMTI are to: • Demonstrate Advanced Medical Technologies and their Impact on Cost, Access and Quality of Care • Provide Senior AMEDD Leadership with Medical Tech-Watch Capability • Encourage Medical Technology Entrepreneurship by Funding AMEDD Technology Innovators

24. Other Collaborative Opportunities • Subject Matter Experts for proposal review and panel review boards. • Job opportunities for graduates or PhD’s looking to work in the medical research arena. • Partnering with existing projects as a subcontractor.

25. Useful Websites • TATRC - www.tatrc.org • USAMRMC BAA 08-1 -www.usamraa.army.mil/pages/Baa-Paa/mrmcbaalist.cfm • USAMRMC Homepage https://mrmc.detrick.army.mil • AMEDD AAMTI Announcement - http://grants.tatrc.org/proposals • Grants.gov – http://www.grants.gov/ • CDMRP - http://cdmrp.army.mil

26. ContactInformation Heather White DoD Research Specialist Office of Sponsored Programs ENG 329 Email: hwhite1@umbc.edu Phone: 410-455-3140