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Smoking and Type-2 Diabetes Mellitus

Smoking and Type-2 Diabetes Mellitus. Toshimi Sairenchi, M.Sc. Ibaraki Health Plaza, Ibaraki Health Service Association, Ibaraki-ken, JAPAN. Contents. Epidemiology of type-2 diabetes mellitus in Japan Smoking and type-2 diabetes mellitus in middle-aged population

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Smoking and Type-2 Diabetes Mellitus

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  1. Smoking and Type-2 Diabetes Mellitus Toshimi Sairenchi, M.Sc. Ibaraki Health Plaza, Ibaraki Health Service Association, Ibaraki-ken, JAPAN

  2. Contents • Epidemiology of type-2 diabetes mellitus in Japan • Smoking and type-2 diabetes mellitus in middle-aged population • Smoking and type-2 diabetes mellitus in elderly population • Possible mechanism • Conclusion

  3. Contents • Epidemiology of type-2 diabetes mellitus in Japan • Smoking and type-2 diabetes mellitus in middle-aged population • Smoking and type-2 diabetes mellitus in elderly population • Possible mechanism • Conclusion

  4. 40% 30% 20% 10% 0% Prevalence of diabetes among Japanese men HbA1c(%)>6.1 or medication 5.6<HbA1c(%)<6.1 without medication Left bar: in 1997 Right bar : in 2002 All age 20-29 30-39 40-49 50-59 60-69 70- Age (years) (Ministry of Health, Labour and Welfare Japan, 2004)

  5. 30% 20% 10% 0% All age 20-29 30-39 Prevalence of diabetes among Japanese women HbA1c(%) > 6.1 or medication 5.6 <HbA1c(%)<6.1 without medication Left bar: in 1997 Right bar: in 2002 40-49 50-59 60-69 70- Age (years) (Ministry of Health, Labour and Welfare Japan, 2004)

  6. Notice • The proportion of diabetes of borderline type increased in the elderly for both sexes. Type-2 diabetes mellitus among elderly is an increasing public health problem.

  7. Contents • Epidemiology of type-2 diabetes mellitus in Japan • Smoking and type-2 diabetes mellitus in middle-aged population • Smoking and type-2 diabetes mellitus in elderly population • Possible mechanism • Conclusion

  8. Follow-up studies for smoking and type-2 diabetes mellitus among middle-aged persons

  9. 2.50 Never smoker <1 Pack per day 2.00 1-1.9 Pack per day >2 Packs per day 1.50 1.00 0.50 0.00 Men Women Sex-specific risk ratios for type-2 diabetes mellitus according smoking habits among 275,190 men and 434,637 women (Will JC. et al., 2001)

  10. Next Question Is there a relationship between smoking and risk of diabetes mellitus among elderly? • Smoking is a risk of diabetes mellitus among middle-aged men and women.

  11. Contents • Epidemiology of type-2 diabetes mellitus in Japan • Smoking and type-2 diabetes mellitus in middle-aged population • Smoking and type-2 diabetes mellitus in elderly population • Possible mechanism • Conclusion

  12. 2.00 Never-smoker Current smoker 1.50 1.00 0.50 0.00 40-59 60-79 Age (years) Age-specific risk ratios for type-2 diabetes mellitus according to smoking habits among 39,528 men, Japan, 1993-2002 (Sairenchi T. et al., 2004)

  13. 2.00 Never-smoker Current smoker 1.50 1.00 0.50 0.00 40-59 60-79 Age (years) Age-specific risk ratios for type-2 diabetes mellitus according to smoking habits among 88,613 women, Japan, 1993-2002 (Sairenchi T. et al., 2004)

  14. Contents • Epidemiology of type-2 diabetes mellitus in Japan • Smoking and type-2 diabetes mellitus in middle-aged population • Smoking and type-2 diabetes mellitus in elderly population • Possible mechanism • Conclusion

  15. One of the possible mechanisms Smoking Oxdative stress Insulin action Diabetes mellitus Bridges AB. et al., 1993 Paolisso G, et el., 1993

  16. Contents • Epidemiology of type-2 diabetes mellitus in Japan • Smoking and type-2 diabetes mellitus in middle-aged population • Smoking and type-2 diabetes mellitus in elderly population • Possible mechanism • Conclusion

  17. Smoking and type-2 diabetes • Smoking is a risk factor of type-2 diabetes mellitus not only among middle-aged but also among elderly men and women.

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