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How Cells Divide

How Cells Divide. Chapter 10. Bacterial Cell Division. Binary Fission FtsZ protein. Eukaryotic Chromosomes. Chromosome Numbers Vary Made of Chromatin. Some Vocab . Karyotype Haploid Diploid Homologue Chromatids. Overview of the Cell Cycle. G1 S G2 M C G0. Interphase.

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How Cells Divide

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  1. How Cells Divide Chapter 10

  2. Bacterial Cell Division • Binary Fission • FtsZ protein

  3. Eukaryotic Chromosomes • Chromosome Numbers Vary • Made of Chromatin

  4. Some Vocab • Karyotype • Haploid • Diploid • Homologue • Chromatids

  5. Overview of the Cell Cycle • G1 • S • G2 • M • C • G0

  6. Interphase • G1, S, G2

  7. Mitosis • Prophase • Prometaphase • Metaphase • Anaphase • Telophase

  8. Prophase • Condensation of Chromosome Contintues • Spindle apparatus • Asters • Nuclear envelope disassembles

  9. Prometaphase • Micrtubules attach to the kinetochore • Chromosomes begin to move toward the equator of the cell

  10. Metaphase • Chromosomes are aligned at the equator of the cell called the metaphase plate • Chromosomes are attached to opposite poles and are under tension

  11. Anaphase • Proteins holding centromeres of sister chromatids are degraded, freeing individual chromosomes • Chromosomes are pulled to opposite poles • Spindle poles move apart

  12. Telophase • Chromosomes are clustered at opposite poles and decondense • Nuclear envelopes reform around chromosomes • Golgi complex and ER re-form

  13. Cytokinesis • Plant vs Animal

  14. Control of the Cell Cycle • Irreversible points • Checkpoints

  15. MPF • Nondividing cells can be stimulated into division by MPF • MPF activity changes throughout the cell cycle • It is cyclin pluc cdc2 (aka Cdk) • What is a kinase?

  16. Three main Checkpoints • G1/S • G2/M • Spindle Checkpoint (APC) • Figure 10.20

  17. Growth Factors • Trigger intracellular signaling systems • RTKs and MAP cascades

  18. G0 Phase • Dormant • Liver vs Intestinal Lining Cells

  19. Cancer • Tumor Suppressor genes- p53, Rb • Oncognes-ProtoOncogenes

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