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ANTIMICROBIAL DRUGS.

ANTIMICROBIAL DRUGS. Introduction. KEY TERMS. Chemotherapy. Antimicrobial Drugs. Chemotherapeutic Agents. Selective Toxicity. Synthetic Drugs. Antibiotics. HISTORY OF CHEMOTHERAPY. Paul Ehrlic. Alexander Fleming. Rene Dubos. Selman Waksman. SPECTRUM OF ANTIMICROBIAL Activity.

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ANTIMICROBIAL DRUGS.

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  1. ANTIMICROBIAL DRUGS. Introduction.

  2. KEY TERMS. • Chemotherapy. • Antimicrobial Drugs. • Chemotherapeutic Agents. • Selective Toxicity. • Synthetic Drugs. • Antibiotics.

  3. HISTORY OF CHEMOTHERAPY. • Paul Ehrlic. • Alexander Fleming. • Rene Dubos. • Selman Waksman.

  4. SPECTRUM OF ANTIMICROBIAL Activity. • Spectrum of Activity. • Broad Spectrum Drugs. • Superinfection.

  5. ACTION OF ANTIMICROBIAL DRUGS. • Inhibition of Cell Wall Synthesis. • Inhibition of Protein Synthesis. • Injury to the Plasma Membrane. • Inhibition of Nucleic Acid Replication and Transcription. • Inhibition of Synthesis of Essential Metabolites.

  6. COMMONLY USED ANTIMICROBIAL DRUGS-Antibacterial Synthesis. • Isoniazid (INH). • Ethambutol. • Sulfonamides. • Quinolones and Fluoroquinolones. • Antifungal synthetics.

  7. ANTIBACTERIAL ANTIBIOTICS. • Penicillin: Natural and Semisynthetic. • Monobactams. • Cephalosporins. • Carbapenems. • Aminoglycosides. • Tetracyclines. • Chloramphenicol.

  8. Macrolides. • Polypeotides. • Vancomycin. • Rifamycins.

  9. OTHER ANTIFUNGAL DRUGS. • Polyenes. • Imidazoles and Triazoles. • Griseofulvin. • Additional Antifungal Drugs. • Antiviral Drugs. • Antiprotozoan and Antihelminthic Drugs.

  10. TESTS TO GUIDE CHEMOTHERAPY-susceptibility testing. • Disk-Diffusion Method. • Broth Dilution Tests.

  11. Effectiveness of Chemotherapeutic Agents. • Drug Resistance. • Effects of Combinations of Drugs. • The Future of Chemotherapeutic Agents.

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