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Immunology Database and Analysis Portal ( ImmPort )

Immunology Database and Analysis Portal ( ImmPort ). Richard H. Scheuermann, U.T. Southwestern 13DEC2010. Outline. Summary of projects supported by ImmPort Semi-public research data in ImmPort Complete representation of clinical research design and results ITN Casale study example

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Immunology Database and Analysis Portal ( ImmPort )

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  1. Immunology Database and Analysis Portal (ImmPort) Richard H. Scheuermann, U.T. Southwestern 13DEC2010

  2. Outline • Summary of projects supported by ImmPort • Semi-public research data in ImmPort • Complete representation of clinical research design and results • ITN Casale study example • Status of Special Pops data submission • Data submission support • Support contacts • Project Blueprints • FLOCK and FlowCAP poster

  3. Projects Supported

  4. 5+ DAIT-funded Programs Browse Data/ ImmPort Research Data/ ImmPort Supported Programs ImmPort Research Data | My Work Bench Population Genetics Analysis Program: Immunity to Vaccines/Infections Program HLA Region Genetics in Immune-Mediated Diseases Program Immune Function and Biodefense in Children, Elderly, and Immunocompromised Populations Program Immune Modeling Centers Other Consortium Projects Reagent Development for Toll-like and other Innate Immune Receptors DMID-funded Centers of Excellence for Influenza Research and Surveillance GlaxoSmithKline – COPD trial

  5. PopGen Browse Data/ ImmPort Research Data/ ImmPort Supported Programs ImmPort Research Data | My Work Bench Population Genetics Analysis Program: Immunity to Vaccines/Infections Program Grants/Contracts/Projects:

  6. HLA Genetics Consortium Browse Data/ ImmPort Research Data/ ImmPort Supported Programs ImmPort Research Data | My Work Bench HLA Region Genetics in Immune-Mediated Diseases Program Grants/Contracts/Projects:

  7. Special Pops Browse Data/ ImmPort Research Data/ ImmPort Supported Programs ImmPort Research Data | My Work Bench Immune Function and Biodefense in Children, Elderly, and Immunocompromised Populations Program Grants/Contracts/Projects:

  8. Immune Modeling Centers Browse Data/ ImmPort Research Data/ ImmPort Supported Programs ImmPort Research Data | My Work Bench Immune Modeling Centers Grants/Contracts/Projects:

  9. Consortium Projects Browse Data/ ImmPort Research Data/ ImmPort Supported Programs ImmPort Research Data | My Work Bench Other Consortium Projects Grants/Contracts/Projects:

  10. ADVN Browse Data/ ImmPort Research Data/ ImmPort Supported Programs ImmPort Research Data | My Work Bench Other Consortium Projects Atopic Dermatitis and Vaccinia Network (ADVN ):

  11. Semi-public completed study ITN Casale

  12. ImmPort home page login

  13. Semi-public workspace projects

  14. Study summary

  15. Study schematic

  16. Additional study summary contents

  17. Study objectives

  18. Additional study summary contents

  19. Study endpoints

  20. Study download packages

  21. Summary of records for download

  22. Download folder of data

  23. Links to external resources

  24. ClinicalTrials.gov record

  25. Data sets - Demographics

  26. ImmPort-calculated summary statistics

  27. Data sets - Assessments

  28. Assessment summaries and links to complete results sets

  29. Assessment results details - Wheal

  30. Links to results

  31. Diastolic Blood Pressure

  32. Data sets – Adverse events

  33. Adverse events broken down by study arm

  34. Data sets – Lab tests

  35. Lab test summaries and links to complete results sets

  36. Hematocrit

  37. Data sets – Mechanistic assays

  38. ELISA and FCM

  39. Experiment samples

  40. Results, protocols, reagents, biological samples

  41. Download of FCM sample sets

  42. Complete representation of a clinical trial in ImmPort

  43. Take home lessons ImmPort is starting to accumulate a lot of interesting immunology research data First completed project dataset made available in semi-public workspace in Oct 2010 All of this data is now readily accessible by both the immunology research community and the study team itself Clinical and translational research is very complex Representation of clinical and translational research is also very complex, but ImmPort has developed a complete infrastructure to support this representation Submission and loading of data into ImmPort is challenging Use BISC support services We still have more to do to make the data maximally accessible and usable

  44. Special Pops submission status

  45. Current submission status

  46. Submission support

  47. BISC contacts Don’t go it alone!! BISC Contacts for Special Population richard.scheuermann@utsouthwestern.edu; 214-648-4115

  48. Data Submission • Mechanistic assays • Metadata – experiment, experiment sample, biological sample, subject, reagent, protocol • Results – FCM, HLA typing, microarray or RT-PCR for expression, ELISA for serum antibody or cytokine, ELISPOT, SNP genotyping • Clinical data • Study design timeline and clinical phenotypes from CRFs collected separately • No PHI

  49. Metadata

  50. Clinical Data Submission 1. Study Design Study design templates 2. Case Report Form Data Mapping of CRF data Load file generation Loading data into the database 3. Experiment Data Submission ImmPort experiment templates

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