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FibroTest in the diagnosis of HCV

FibroTest in the diagnosis of HCV. Publications on diagnostic performance. In this Presentation. Diagnosis and clinical options. Positive serology. Poynard et al, Comp Hepatol 2004. First validation study. Imber-Bismut et al, Lancet 2001.

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FibroTest in the diagnosis of HCV

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  1. FibroTest in the diagnosis of HCV Publications on diagnostic performance FT in diagnostic of HCV

  2. In this Presentation FT in diagnostic of HCV

  3. Diagnosis and clinical options Positive serology FT in diagnostic of HCV Poynard et al, Comp Hepatol 2004

  4. First validation study FT in diagnostic of HCV

  5. Imber-Bismut et al, Lancet 2001 • Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study (n=205) • The top and bottom of the box are the 25th and 75th percentiles. • The length of the box is thus the IQR. The line through the middle of the box is the median. • The upper error bar is the largest observation 75th percentile plus 1·5IQR. • The lower error bar is the smallest observation that is 25th percentile minus 1·5IQR. • Bonferroni allpairwise multiple comparison; p<0·0001 between all stages. FT in diagnostic of HCV

  6. Imber-Bismut et al, Lancet 2001 ROC curves of fibrosis indices combining five, six, or ten biochemical factors, and age and sex FT in diagnostic of HCV

  7. FibroTest in histological changes FT in diagnostic of HCV

  8. D’Arondel JVHep 2006 • Utility of biomarkers to estimate the dynamics in the histological response in HCV to pegylated-IFN alpha-2b and ribavirin n=96 FT in diagnostic of HCV

  9. Poynard et al, Hepatology 2003 • Biochemical Surrogate markers of liver fibrosis and activity in a randomized trial of Peginterferon Alfa-2B and ribavirin FT in diagnostic of HCV

  10. Poynard et al, Hepatology 2003 - Results FT in diagnostic of HCV

  11. FibroTest in HCV carriers with mixed cryoglobulinemia systemic vasculatis FT in diagnostic of HCV

  12. Sene D. et al, Clin Biochem 2006 • Biochemical markers of liver fibrosis and activity as non invasive alternatives to liver biopsy in patients with CHC and mixed cryoglobulinemia vasculatis (MCV) FT in diagnostic of HCV

  13. Sene D. et al, Clin Biochem 2006 No vasculatis Vasculatis FT in diagnostic of HCV

  14. Comparison and combination with other methods Hyaluronic acid, Historical index, Apri, FirboScan FT in diagnostic of HCV

  15. FibroTest versus other non invasive markersPoynard et al, Comp Hepatol 2004 • Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic Hepatitis C Study Design FT in diagnostic of HCV

  16. FibroTest versus other non invasive markersPoynard et al, Comp Hepatol 2004 - Results FT in diagnostic of HCV

  17. FibroTest versus other non invasive markersPoynard et al, Comp Hepatol 2004 - Results FT in diagnostic of HCV

  18. FibroTest Historical index FibroTest Historical index FibroTest versus BiopsyMyers R.P et al, American Journal of Gastro 2002 • Biochemical markers of liver Fibrosis: a comparison with historical features in patients with chronic Hepatitis C FT in diagnostic of HCV

  19. Sebastiani et al, J Hepatol 2006 • Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C FT in diagnostic of HCV

  20. Sebastiani et al, J Hepatol 2006 – Safe Biopsy • Sequential Algorithms for Fibrosis Evaluation (SAFE BIOPSY) Stepwise modelling aimed to achive accuracy> 95% FT in diagnostic of HCV

  21. Sebastiani et al, J Hepatol 2006 – Biopsy and cost reduction • Sequential Algorithms for Fibrosis Evaluation (SAFE BIOPSY)INTERIM ANALYSIS ON 2035 HCV CASES FT in diagnostic of HCV

  22. FibroTest versus Glycomics and FibroScan- Castera et al, Gasteroenterol Clin Biol 2005 • “Clinical glycomics”: independant validation and comparison with Fibroscan and FibroTest for the assessment of fibrosis in CHC FT in diagnostic of HCV

  23. FibroTest versus FibroScan- Castera et al, Gastroenterology 2005 • Prospective comparison of transient elastography, FibroTest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. FT in diagnostic of HCV

  24. Multi center validation study: FibroTest versus HA- Poynard et al, J viral Hepat 2002 • Biochemical markers of liver fibrosis in patients infected by hepatitis C virus: longitudinal validation in a randomized trial (n=165) FT in diagnostic of HCV

  25. Meta analysis FT in diagnostic of HCV

  26. Meta-analysis – Poynard et al, clin chem 2007 FibroTest Meta-Analysis 30 Published Studies 6.378 Patients 2001-2006 AUROC=0.84 (0.83-0.86) for F2F3F4 The best you can obtain with 20mm biopsy is 0.90 Bedossa 2003 FT in diagnostic of HCV

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