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The Role of Multivitamins in Paediatric HIV Management in Nigeria: A Randomized Controlled Study

This study aims to determine the impact of multivitamins on health outcomes in paediatric HIV management in Nigeria. The study explores whether higher strength multivitamins can provide better health outcomes compared to lower strength multivitamins, with CD4 count and haemoglobin levels being the primary and secondary outcomes, respectively. The study found a significant increase in haemoglobin concentration and a reduction in the prevalence of anaemia after 3 months of multivitamin use. However, there was no significant increase in CD4 count observed. These findings support the use of multivitamins in pediatric individuals living with HIV.

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The Role of Multivitamins in Paediatric HIV Management in Nigeria: A Randomized Controlled Study

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  1. The Role of Multivitamins in Paediatric HIV Management in Nigeria: A Randomized Controlled Study

  2. Background • The signature of Human Immunodeficiency Virus (HIV) infection is immune deficiency • Management involves the use of combination antiretroviral drugs • Multivitamins are also being used • A vicious cycle between micronutrient deficiency, immune deficiency and HIV disease progression has been reported in a number of studies

  3. Vicious cycle between HIV infection and micronutrient deficiencies

  4. Research objectives • To determine the effect of multivitamins on health outcomes • To determine if higher strength multivitamins may be able to provide better health outcomes compared to lower strength multivitamins • -Primary outcome: CD4 count • -Secondary outcomes: Haemoglobin (Hb) levels

  5. Methodology

  6. Results Significant increase in Hb conc. after 3 months No significant change in CD4 count after 3 months

  7. Resultssignificant reduction in prevalence of anaemia after 3 months multivitamin use P= 0.004 Anaemia status at baseline Anaemia status after 3 months

  8. ResultsNo change in prevalence of immune deficiency after 3 months, P=0.405 Immune status at baseline Immune status after 3 months

  9. RESULTS • Multi-micronutrient group assignment did not influence outcomes

  10. Discussion • After 3 months of multivitamin use, no significant increase in CD4 count was observed. Hb concentration was increased and prevalence of anaemia was reduced. • So far, this study therefore supports multivitamin use in PLHIV.

  11. Thank you.

  12. References • Fawzi, W., Msamanga, G., Kupka, R., Spiegelman, D., Villamor, E., Mugusi, F., Wei, R. and Hunter, D. (2007) ‘Multivitamin supplementation improves hematologic status in HIV-infected women and their children in Tanzania’, The American journal of clinical nutrition., 5(85) • National Agency for the Control of AIDS (NACA) (2015) Global AIDS response. Country Progress Report, Nigeria GARPR 2015. Available at: http://www.unaids.org/en/regionscountries/countries/nigeria • Semba, R. and Tang, A. (1999) ‘Micronutrients and the pathogenesis of human immunodeficiency virus infection.’, The British journal of nutrition., 3(81)

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