1 / 29

Enzymes

Learn about enzymes, their active sites, cofactors, inhibitors, and the effects of temperature and pH. Discover how drugs can act as enzyme inhibitors.

ythompson
Download Presentation

Enzymes

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Enzymes

  2. Enzyme Active Site • Amino acid side chains interact, metal ions, • Various types of polar, non-polar, ionic interactions

  3. Enzyme Active Site • Amino acid side chains interact, metal ions, • Various types of polar, non-polar, ionic interactions

  4. Enzymes • Lock and Key Analogy: lock = enzyme, key = substrate.

  5. Enzymes • Lock and Key Analogy: lock = enzyme, key = substrate.

  6. Induced Fit Theory • Enzyme is not rigid, changes shape with substrate.

  7. Induced Fit Theory • Enzyme is not rigid, changes shape with substrate.

  8. Enzymes - Cofactors • Coenzymes (contain a vitamin) or metal ion

  9. Enzymes - Cofactors • Metal ions present in trace amounts

  10. Enzymes - Cofactors • Metal ions present in trace amounts

  11. Enzyme Cofactors • Coenzyme - non protein organic, maybe a vitamin.

  12. Enzyme Cofactors • Coenzyme - non protein organic, maybe a vitamin.

  13. Enzyme Cofactors • Coenzyme - non protein organic, maybe a vitamin.

  14. Enzymes

  15. Enzymes - Activity • Temperature and pH effect enzyme action

  16. Enzymes - Activity • Temperature and pH effect enzyme action

  17. Enzymes - Activity • Enzyme and substrate concentrations

  18. Enzymes - Inhibitors • Nonspecific - denaturation, pH, temperature

  19. Enzyme Inhibitors • Noncompetitive

  20. Enzyme Inhibitors • Competive - mimic substrate, may block active site, but may dislodge it.

  21. Enzyme Inhibitors • Competive - mimic substrate, may block active site, but may dislodge it.

  22. Enzyme Inhibitors

  23. Enzyme Inhibitors • Irreversible - covalently binds to active site

  24. Enzyme Inhibitors • Regulator or feedback - used to control a sequence of reactions - reaction product may block initial enzyme.

  25. Enzyme Inhibitors • Regulator or feedback - used to control a sequence of reactions - reaction product may block initial enzyme.

  26. Enzyme Inhibitors

  27. Enzyme Inhibitors

  28. Drugs as Enzyme Inhibitors • Drug mimics some natural chemical to block enzyme.

  29. Drugs as Enzyme Inhibitors • Drug mimics some natural chemical to block enzyme.

More Related