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Cold agglutinin syndrome following allogeneic transplant

Case. 57 year-old man with a history of chronic lymphocytic leukemia (CLL).Diagnosed in 1993.Lymphocytosis and adenopathy.Treated with ProMACE-CytaBOM: Procarbazine, mechlorethamine, adriamycin, cyclophosphamide, etoposide, cytarabine, leuvorin, methotrexate.Achieved a remission.. Case. Relapsed

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Cold agglutinin syndrome following allogeneic transplant

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    1. Cold agglutinin syndrome following allogeneic transplant Joshua Field January 13, 2006

    2. Case 57 year-old man with a history of chronic lymphocytic leukemia (CLL). Diagnosed in 1993. Lymphocytosis and adenopathy. Treated with ProMACE-CytaBOM: Procarbazine, mechlorethamine, adriamycin, cyclophosphamide, etoposide, cytarabine, leuvorin, methotrexate. Achieved a remission.

    3. Case Relapsed 1997. Thereafter Chlorambucil CVP Fludarabine Rituximab Cyclophosphamide, fludarabine, rituximab Referred for an allogeneic transplant. Workup allogeneic transplant: +ZAP70 cytogenetics 48 XY, trisomy 12, 19 in 5 metaphases, deletion 7 in 1 metaphase.

    4. Case 8/19/05: Day 0 Fludarabine, busulfan, thymoglobulin 6/6 matched sibling transplant. Reduced conditioning regimen: Previous therapy Graft versus tumor effect OPos into OPos Course complicated by fevers with thymoglobulin. Discharged on 8/30/05 on FK-506.

    5. Case 9/4/05: Day +17 presented with malaise and fevers. 2-3 day history of fatigue. Poor PO intake. Low-grade fevers 100.8. Admitted to 5900 and bloodwork sent.

    6. Case

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