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ormagi daniSnuleba: finkis angariSi

ormagi daniSnuleba: finkis angariSi. leqcia # 14. I. mimoxilva. ormagi daniSnulebis koncefcia slaidebi 2 - 6 finkis komitetis angariSi angariSis miznebi da struqtura slaidebi 7 - 10 angariSis rekomendaciebi slaidebi 11 - 14 saeWvo eqsperimentebi slaidebi 15 - 20.

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ormagi daniSnuleba: finkis angariSi

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  1. ormagi daniSnuleba: finkis angariSi leqcia # 14

  2. I. mimoxilva • ormagi daniSnulebis koncefcia • slaidebi 2 - 6 • finkis komitetis angariSi • angariSis miznebi da struqtura • slaidebi 7 - 10 • angariSis rekomendaciebi • slaidebi 11 - 14 • saeWvo eqsperimentebi • slaidebi 15 - 20

  3. 2. ormagi daniSnuleba (i) • tradiciulad “ormagi daniSnulebis” koncefcia aRwers samxedroebis mier SemuSavebul teqnologiebs, romlebic samoqalaqo miznebisTvis iqna gamoyenebuli. am gziT gamoyenebuli samxedro teqnologiis magaliTi aris interneti. • amJamad, sasicocxlo mecnierebebTan mimarTebaSi, es koncefcia moicavs masalebs, teqnologiebsa da codnas, romelic SemuSavebul iqna keTili samoqalaqo miznebiT, magram SeiZleba sxvebis mier mtruli miznebiT iqnas gamoyenebuli.

  4. 3 ormagi daniSnuleba (ii) • niusuiki, 2007 • “…naTelia, rom sasicocxlo mecnierebi iseve Searyeven samyaros 21-e saukuneSi, rogorc fizikam Searyia samyaro me-20 saukuneSi, sul ramodenime weliwadSi SesZlebs eqimi Caataros Tqveni piradi genomis analizi da miiRos Tqveni janmrTelobis perspeqtivis detaluri profili… axali teqnologia, romelsac rnm interferencia ewodeba, aseve miscems sasualebas Tqvens eqims gaakontrols, rogor xdeba Tqveni dnm-is “gamovlena” , da dagexmarebaT Tavidan aiciloT janmrTelobis potenciuri riskebi…”

  5. 4. ormagi daniSnuleba (iii) • bioregulatorebi, rogorc teroris saSualeba • “…bioregulatorebi aris struqturulad gansxvavebuli naerTebi, romelTac unari seswevT areguliron fiziologiuri movlenebis farTo speqtri, magalitad, bronquli da sisxlZarRvovani tonusi, kunTebis SekumSva, sisxlis wneva, guliscemis ritmi, temperatura da imunuri pasuxi. es nivTierebebi, Tu isini maRali koncentraciiT an Secvlili bunebiT an moqmedebis xangrZlivobiT gamoiyeneba, SeiZleba iyos zianis momtani, …”

  6. 5. ormagi daniSnuleba (iv) • ramodenime magaliTi bioregulatorebisa, romlebic SeiZleba gamoyenebul iqnas • citokinebi • mag. IL-1, IL-6 • eikozanoidebi • mag. PGD2, LTC4 • neirogadamtanebi da hormonebi • mag. kateqolaminebi, neiropeptidebi, insulini • plazmis proteazebi • kalikreini, bradikinini

  7. 6. ormagi daniSnuleba (v) • bioregulatorebis upiratesobebi TavdamsxmelTaTvis • advilad xelmisawvdomia • klinikuri zemoqmedeba araspecifiuria • moqmedebis swrafi gamovlineba • ar arian saSiSi agentebis standartul siebSi • ar arsebobs vaqcinebi • farTod gavrcelebis potenciali

  8. 7. finkis komitetis angariSi: mizani/struqtura (i) • bioteqnologiuri kvleva terorizmis eraSi • “miuxedavad imisa, rom erovnulma akademiebma mravali angariSi moamzades erovnuli usafrTxoebis Sesaxeb, umniSvnelovanesia gansakuTrebuli yuradReba mieqces erovnul usafrTxoebasa da sasicocxlo mecnierebebs….am mxriv sasicocxlo mecnierebebSi bevri ram moxda iseTi, rac axsnas moiTxovs – aRmoCena, rom arsebobs erebi, romelTac aqvT biologiuri iaraRis Seqmnaze mimarTuli saidumlo programebi, jilexis Seteva 2001 wels, bioteqnologiis progresis swrafi tempi, da am axali teqnologiebis xelmisawvdomoba…”

  9. 8. finkis komitetis angariSi: mizani/struqtura (ii) • komitetis Sexeduleba ormagi daniSnulebis problemaze • “…Cvenma komitetma ganixila am speqtris erT-erTi mniSvnelovani nawili…SesaZlo arasworad gamoyenebis: biologiuri kvleviTi saqmianobis SesaZlebloba gamoiqvios ngreva an moutanos ziani.... ufro zogadad, es SesaZlebloba ori elementisagan Sedgeba: • (1) riski, rom saSiSi agentebi, romlebzedac kvleva warmoebs, SeiZleba moparul iqnas an gamoyenebuli iyos mtruli miznebiT; da (2) riski, rom kvlevis Sedegebma, codnam, an teqnikam SeiZleba xeli Seuwyos “axali” paTogenebis Seqmnas, romelTac eqnebaT unikaluri Tvisebebi an sasiSi agentebis sruliad axal klass warmoadgenen…”

  10. 9. finkis komitetis angariSi: mizani/struqtura (iii) • saerTaSoriso ganzomileba • “Tumca angariSi fokusirebulia SeerTebul Statebze, es qveyana aris erTaderTi, romelic bioteqnologiur kvlevebs umaRles doneze atarebs…. absoluturad marTebulia SeerTebuli StatebisaTvis, rom Seqmnas sistema, romelic gaakontrolebs kvleviT saqmianobas qveynis SigniT, magram es mcdeloba bevrs arafers moitans, Tu saerTaSorisod ar iqna miRebuli…”

  11. finkis komitetis angariSi: mizani/struqtura (iv) • angariSis struqtura: • 1. Sesavali • 2. sasicocxlo mecnierebis ganviTarebadi regulatoruli buneba 21-e saukuneSi • 3. informaciis SeZRudva da kontrolis reJimebi • 4. daskvnebi da rekomendaciebi

  12. 11. finkis komitetis angariSi: rekomendaciebi (i) • angariSis rekomendaciebi • “1. samecniero sazogadoebis ganaTleba • Cveni rekomendacia iqneba, rom erovnulma da saerTaSoriso profesiulma sazogadoebebma da monaTesave organizaciebma Seqmnan saganmanaTleblo programebi mecnierebisaTvis bioteqnologiaSi ormagi daniSnulebis dilemis Bunebis da riskis Semcirebis saqmeSi maTi pasuxismgeblobis Sesaxev.”

  13. 12. finkis komitetis angariSi: rekomendaciebi (ii) • “2. eqsperimentebis gegmebis ganxilva • Cveni rekomendacia iqneba, rom janmrTelobisa da humanuri samsaxuris departamentma (Department of Health and Human Services - DHHS) gaafarTovos janmrTelobis erovnuli institutebis (National Institutes of Health ) rekombinantuli dnm-is gamoyenebiT warmoebuli eqsperimentebis ganxilvis arsebuli sistema da Seqmnas ganxilvis sistema eqsperimentebis Svidi klasisaTvis (preblemuri eqsperimentebi), romlebic tardeba im mikrobuli agentebis gamoyenebiT, romelTa araswori gamoyeneba qmnis problemas.”

  14. 13. finkis komitetis angariSi: rekomendaciebi (iii) • 3. ganxilva publikaciis etapze • “Cven rekomendacias vuwevT mecnierebisa da samecniero Jurnalebis TviTmmarTvelobas publikaciebis ganxilvaSi maTi potenciuri erovnuli usafrTxoebis riskis mixedviT. • ….kvlevis Sedegebis publikacia gvaZlevs maTi farTod gavrcelebis saSualebas, maT Soris maTTanac, vinc SeiZleba isini arasworad gamoiyenos. swored amitom upriani iqneba ganvsazRvroT, ganxilvis rogori procedurebi unda dadgindes publikaciisaTvis, raTa dacvis Semdegi safexuri Seiqmnas…”

  15. 14. finkis komitetis angariSi: rekomendaciebi (iv) • “4. biologiuri dacvis erovnuli samecniero mrCevelTa sabWos Seqmna • Cven rekomendacias vuwevT, rom janmrTelobisa da humanuri samsaxuris departamentma Seqmnas biologiuri dacvis erovnuli samecniero mrCevelTa sabWo (National Science Advisory Board for Biodefense -NSABB), romelic rCevebs miscems, uxelmZRvanelebs da gauZRveba Cvens mier semoTavazebul ganxilvisa da kontrolis sistemas.”

  16. 15. finkis komitetis angariSi: saeWvo eqsperimentebi (i) • “komitetma gansazRvra eqsperimentebis Svidi klasi, romlebic, misi azriT, asaxavs im mcdelobebs an armoCenebs, romlibis moiTxovs samecniero da samedicino sazogadoebis informirebuli wevrebis mxridan ganxilvas, vidre isini ganxorcieldeba, an, Tu ganxorcielda, vidre isini detalurad gamoqveyndeba…”

  17. 16. finkis komitetis angariSi: saeWvo eqsperimentebi (ii) • “aq CamoTvlili Svidi problemuri are mxolod potenciur mikrobul safrTxes exeba….Tumva, droTa ganmavlobaSi, komitets swams, rom aucilebeli gaxdeba…problemuri areebis gafarToeba, raTa daifaros sagrZnoblad adamianis, cxovelebis an naTesebis potenciuri safrTxeebis ufro didi are…”

  18. 17. finkis komitetis angariSi: saeWvo eqsperimentebi (iii) • problemuri eqsperimentebi iqneba Semdegi • 1. romlebic aCvenebs, rogor gavxadoT vaqcina araefeqturi. es exeba rogorc adamianis, aseve sxovelur vaqcinebs. • 2. gamoiwvevs rezistentobas Terapiulad saWiro antibiotikebis an antivirusuli agentebis mimarT. es exeba Terapiul agentebs, romlebic gamoiyeneba agentebis kontrolisaTvis adamianebSi, cxovelebsa da naTesebSi. ciprofloqsacinisadmi rezistentobis gamowveva Bacillus anthracis–Si am klass ganekuTvneba.”

  19. 18. finkis komitetis angariSi: saeWvo eqsperimentebi (iv) • “3. gaaZlierebs paTogenis virulentobas an arapaTogenSi virulentobas gamoiwvevs. es exeba mcenareebis, cxovelebisa da adamianis paTogenebs. cereolizinis toqsinis genis Seyvana Bacillus anthracis–Si am klass ganekuTvneba. • 4. gaaZlierebs paTogenis gadacemis unars. es exeba gadacemis unaris gaZlierebas saxeobis SegniT an saxeobebs Soris. am klass ganekuTvneba veqtoris Secvla gadacemis unaris gasazrdelad.”

  20. 19. finkis komitetis angariSi: saeWvo eqsperimentebi (v) • “5. secvlis paTogenis maspinZlebis areals. es moicavs arazoonozuri agentis zoonozurad gadaqcevas. am klass ganekuTvneba virusebis tropizmis Secvla. • 6. saSualebas miscems gausxltes sadiagnos tiko. deteqciis meTodebs. es SeiZleba moicavdes mikrokapsolebSi CatvirTvas, rac saSualebas miscems Tavidan aicilos antisxeulebze damyarebuli deteqcia da/an genuri sekvensis cvlileba aacdens molekuluri biologiis meTodebiT deteqcias.”

  21. 20. finkis komitetis angariSi: saeWvo eqsperimentebi (vi) • “7. biologiuri agentis an toqsinis iaraRad gakeTebis saSualebas iZleva. es SeiZleba moicavdes paTogenis garemoSi stabilizacias.” • angariSSi aRniSnulia, rom • “yvela eqsperimenti, romelic amJamad Svid problemur areSi xvdeba, moiTxovs ganxilvas instituciuri biousafrTxoebis sabWos mxridan (ibs)…amrigad, Cven rekomendacias vuwevT ibs sistemebze , rogorc problemuri eqsperimentebis pirvel etapze, dayrdnobas..”

  22. sanimuSo SekiTxvebi 1. raSi mdgomareobs “ormagi daniSnulebis” Tanamedrove koncefcia? moiyvaneT im eqsperimentebis sami magaliTi, romlebmac SeiZleba ormagi daniSnulebis mxriv dagvaeWvos. 2. fiqrobT, rom sasicocxlo mecnierebebis miRwevebi gazrdis ormagi daniSnulebis eqsperimentebis ricxvsa da tipebs? 3. aRwereT finkis angariSis struqtura. rogor fiqrobT, romlebia yvelaze mniSvnelovani rekomendaciebi? 4. imsjeleT eqsperimentebis Svid klasze, romlebic gamohyo finkis komitetma gansakuTrebuli yuradRebis misaqcevad. es yvela is eqsperimentia, romlebic potenciur eWvs badebs?

  23. wyaroebi (slaidi2) Atlas, R. M. and Dando, M. R. (2006) The Dual-Use Dilemma for the Life Sciences: Perspectives, Conundrums, and Global Solutions. Biosecurity and Bioterrorism, 4 (3), 276- 286. Available from http://www.liebertonline.com/bsp?cookieSet=1 (slaidi3) Silver, L. (2007) ‘Science: The Year of Miracles’, Newsweek, 15th October, pp. 40 - 49. Available from http://www.brad.ac.uk/acad/sbtwc/test/italy/lecture14files/LeeSilver/LeeSilver.htm (slaidi4) Kagan, E. (2001) Bioregulators as Instruments of Terror, Clinics in Laboratory Medicine, 22(3), pp. 607 - 618. Available from http://www.labmed.theclinics.com/ (slaidi 7) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=R7

  24. (slaidi 8) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=1 (slaidi 9) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=2 (slaidi 10) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=15 (slaidi 11) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=107

  25. (slaidi 12) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=5 (slaidi 13) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=116 (slaidi 14) National Institute of Health Office of Science Policy (2008) About NSABB. Available from http://oba.od.nih.gov/biosecurity/about_nsabb.html#xxPAGETOP The Secretary of Health and Human Services (2008) Charter: National Science Advisory Board for Biosecurity, Washington, D. C. Available from http://oba.od.nih.gov/biosecurity/PDF/NSABB_Charter_508_accessible.pdf (slaidi 15) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=107

  26. (slaidi 16) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=114 (slaidi 17) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=114 (slaidi 18) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=114 (slaidi 19) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=115 (slaidi 20) National Research Council (2004) Biotechnology Research in an Age of Terrorism. Washington: National Academies Press. Available from http://books.nap.edu/openbook.php?record_id=10827&page=115

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