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Ethanol

Ethanol. Chmátalová Zuzana. Ethanol. Primary alcohol Polar bounds Miscible with polar resolvents ( water ) Preparation : sugar fermentation or catalytic hydratation of ethylene. Oxidative degradation. Alcohol dehydrogenase ―> Aldehyde dehydrogenase

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Ethanol

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  1. Ethanol Chmátalová Zuzana

  2. Ethanol • Primaryalcohol • Polarbounds • Misciblewithpolarresolvents (water) • Preparation: sugarfermentationorcatalytichydratationofethylene

  3. Oxidativedegradation • Alcoholdehydrogenase ―>Aldehyde dehydrogenase • Microsomalethanoloxidizingsystem • Cytochrome P-450 • IsoenzymeCYP2E1 • Catalase

  4. Non-oxidativedegradation • Rareprocess • 2 ways: • Formtationofethylestersoffattyacids • Formationofphosphatidylethanol • Non-oxidativereactionsincrease in chronicalcoholics

  5. Effectsofalcoholmetabolism • Changes in energeticmetabolism • Changes in cell redoxstate • Liver hypoxia • ROS production

  6. Acetaldehyde • Reactswith: • Lysine • Cysteine • Aromaticamino-acids • Induces: • Imunerespons • Colagensynthesis • Oxidative stress • Changes in proteinsand DNA

  7. literature • S. Zakhari, Howisalcoholmetabolised by the body?,AlcoholResearch&Health 29 (4), 2006 • P. Hůlek, I. Hrubá, Poškození jater alkoholem, ČLS JEP, 2002 (http://www.cls.cz/dp) • http://alkohol.klobuckamafie.cz/images/ach-ty-deti.jpg • http://alkoholismus.wz.cz/diagnostika_naduzivani_alkoholu.htm • http://www.at-konference.cz/data/document/20100525/02_zima_metabolismus_AT2010_1.pdf?id=417 • Koolmanetal., Barevný atlas biochemie, GRADA, 2012, str. 326

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