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RNA Ribonucleic Acid. &. Protein Synthesis. 8.4, 8.5, 8.7. Central dogma Transcription Translation Codon Anticodon. Start codon Stop codon Mutation Point mutation Frameshift mutation mutagens. Protein Synthesis Terms define these 11 terms for homework.
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RNARibonucleic Acid & Protein Synthesis 8.4, 8.5, 8.7
Central dogma Transcription Translation Codon Anticodon Start codon Stop codon Mutation Point mutation Frameshift mutation mutagens Protein Synthesis Termsdefine these 11 terms for homework
The Central Dogma of Molecular BiologyFrancis Crick Information flows in one direction DNARNAProteins Replication Transcription Translation
Structure of RNA3 main differences between RNA and DNA • 1. Sugar in RNA isribose • 2. RNA is single stranded • 3. RNA contains uracil in place of thymine
Three Types of RNA • Messenger RNAmRNA- carries message from DNA to ribosome • Ribosomal RNArRNA- forms part of a ribosome reads message and assembles protein at ribosome • Transfer RNAtRNA- brings amino acids from cytoplasm to ribosome to help make protein
The Process of Protein Synthesis Staring m RNA r RNA t RNA Act 1: Transcription Act 2: Translation
Transcriptionprocess where a complementary strand of m RNA is formed from DNA Scene: The nucleus
Transcription • 1. Enzyme (RNA Polymerase) separates DNA strand • 2. One strand of DNA used as template to assemble strand of m RNA.
TranslationInformation from DNA is translated into a protein Takes place at the ribosome In the Cytoplasm
Translation- Translating language of nucleic acids (base sequences) into language of proteins (amino acids) • 1. Gene on DNA carries code to make protein • a. Code written in language with only 4 “letters”, the nitrogen bases A,C,G,U • b. Code read 3 letters at a time, each 3 letter “word” known as a codon
Process uses all 3 types of RNA • a. mRNA from nucleus travels to ribosome • b. rRNA at ribosome reads genetic code from mRNA , calls for appropriate tRNA
The Genetic Code consists of 20 amino acids
c. Each tRNA has an anticodon whose bases are complementary to codon on mRNA. tRNA brings amino acids to ribosomes anticodon codon
d. Ribosome moves along mRNA, binding new tRNA molecules and amino acids
Mutations • Change in the DNA • May or may not be expressed • Can be beneficial or lethal • Can be spontaneous or caused by exposure to radiation or toxic chemicals (mutagens)
Point mutation one nucleotide is substituted for another
Frameshift MutationChanges the way the DNA is read THE CAT ATE THE RAT Remove the E THC ATA TET HER AT • The insertion or deletion of a nucleotide