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NEUROFIBROMA

NEUROFIBROMA. Amir Yari. Mashhad University of Medical Sciences Dentistry Faculty. NEUROFIBROMA. The neurofibroma is the most common type of peripheral nerve neoplasm . It arises from a mixture of cell types Including Schwann cells and perineural fibroblasts . Clinical Features.

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NEUROFIBROMA

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  1. NEUROFIBROMA Amir Yari Mashhad University of Medical Sciences Dentistry Faculty

  2. NEUROFIBROMA • The neurofibroma is the most common type of peripheral nerve neoplasm . • It arises from a mixture of cell types Including Schwann cells and perineural fibroblasts.

  3. Clinical Features • Neurofibromas can arise as solitary tumors or be a component of neurofibromatosis. • Tumors are most common in young adults. • They are present as: • Slow-growing • Soft • Painless • Vary in size (from small nodules to larger masses.)

  4. Clinical Features • The skin is the most frequent location for neurofibromas. • Lesions of the oral cavity are not uncommon. • The tongue and buccal mucosa are the most common intraoral sites.

  5. Clinical Features

  6. Radiographic Features • On rare occasions the tumor can arise centrally within bone. • where it may produce a welldemarcated or poorly defined unilocular or multilocular radiolucency.

  7. Histopathologic Features • The solitary neurofibroma often is well circumscribed.(especially when the proliferation occurs within the perineurium of the involved nerve) • Tumors that proliferate outside of the perineu rium may not appear well demarcated and tend to blend with the adjacent connective tissues.

  8. Histopathologic Features • The tumor is composed of in terlacing bundles of spindle-shaped cells that often exhibit wavy nuclei. • Mast cells tend to benumerous and can be a helpfull diagnostic feature. • Sparsely distributed small axons usually can be demonstrated within the tumor tissue by using silver stains. • lmmunohistochemically the tumor cells show a scattered positi ve reaction for S-100 protein .

  9. Histopathologic Features

  10. Treatment and Prognosis • The treatment for solitary neurofibromasis local surgical excision. • Recurrence is rare. • Any patient with a lesion that is diagnosed as a neurofibroma should be evaluated clinically for the possibility of neurofibromatosis. • Malignant transformation of solitary neurofibromas can occur(although the risk appears to be remote.)

  11. Thank you Email: amir.yari@hotmail.com

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