Wond-r-Ful

1. Wond-r-Ful Wound and Burn Treatment Wond-r-Ful is an authorized trade name for distribution of the AquaMed formulation combined with Aloe Vera.

2. What does it contain? • Ultra pure water • Aloe Vera • Sodium • Silicate • Sulfate of Ester of Oil of Euphorbiaceae • Magnesium • Calcium • Chloride

3. What are its properties? Silica – acts as anti-yeast, anti-fungal Membrane stabilizer – but not a steroid – no coal tar Soothing – alkaline (8.0) Pain relieving – through depolarization of nerve pain cell junction Kills certain bacteria – Staph, Strep, E-coli, Pseudomonas (SA Institute for Medical Research #CGM0309907) Skin absorption to depth of 2mm – ideal for burns Non-carcinogenic, non-mutagenic and non-irritating to the skin and eyes(WARF INSTITUTE, INC. Madison, WI No. 6073661)

4. Primary Use - Burn & Wound Treatment • Bacteriocidal – swabs showed ‘no growth’ of Staph. A., Pseudo-monis, Streptococcus – keeping the sight free of infection • Relieves pain quickly flooding the calcium channels and depolarizing nerve junctions • Rapid promotion of the healing process by driving magnesium and sodium to the cell level • Rapid healing should reduce long term scarring • Patient comfort is increased due to ease of application - spraying Wond-r-Ful vs coating burn or wound area with Silvadene Cream or Betadene.

5. How else is it used? • Babies in diapers (diaper rash) (burns, skin infections) (umbilical cord site not healing) • Children (anti-septic wound dressing) (scrapes, cuts, burns) (little girl’s vaginitus) (itching and infected eyes) • Adults (burns, sunburn) (itching and infected eyes) (diabetic leg sores) (anti-septic healing agent) (psoriasis treatment) (vaginal itch) (intertrigo fungal treatment) (athlete’s foot) • Nursing Homes (decubitous bed sores) • Restaurants (burns, scrapes, cuts) • Industrial (burns, scrapes, cuts) (anti-septic cleansing) • Professionals (cleansing hands before touching patients)

6. As with discovering that taking Aspirin helps prevent heart attacks, new uses for Wond-r-Ful are still being discovered • We've had reports back from missionaries that they spray it in puss-filled ears of children with AIDS in East Africa and in their infected eyes and all sorts of sores and wounds. My daughter uses it for diaper rash. A friend in China used it for athlete's foot (he called it "stinky feet"). I use it for my itchy eyes often found in Florida. • LH, RN

7. Quoting an RN … • It's great stuff and my wife, who is an RN, used it in a Camp Health Service in NH last summer. She sprayed it on so many kids she stopped counting - even for pink eye! Imagine kids sliding into home base, all sorts of scrapes from falls and kicks from soccer games, sunburn, a stubbornly infected toe, but mostly from infected lesions (like pimples or from scratching mosquito bites) – you get the picture! • JH, Retired Hospital Administrator, FL

8. And another… From a Type II Diabetic: • I often get sinus problems and infections/irritations in my eyes, along with "dry eye", and so on.   My brother said that he knew a natural product which might be just the thing for me:  Wond-r-Ful.  He said that he had an extra bottle that he'd give me, which he dropped by the next day. I put some of it into a smaller spray bottle for ease of use for my eyes and just spray it on when I'm having any problem; and I've been thanking the Lord for it -- it's great! I find it so gentle and soothing in my eyes whenever they are irritated and wonderful on any facial skin problems. • Another problem I suffer with (literally) is called Intertrigo. Well, nothing has been of any lasting, deep help in treating and relieving that problem until now.  Wond-r-Fulreally does help. CG, PA

9. Wonderful for Diaper Rash • “Wond-r-Ful also has silica in it. Silica acts as an anti-yeast, or anti-fungal ingredient. I have had a number of women talk to me about its use in the bassinette area with their baby where their infant has had a bad case of diarrhea and has developed severe diaper rash. I had a patient come to me recently who had a child who was about a year old, but had a chronic diarrhea condition and with it chronic diaper rash. She used Wond-r-Ful, and six hours later I got a call from her. She said, “you won’t believe it.” “This rash is almost all gone.” All within four to six hours.” • “A study was also done with Wond-r-Ful at a nursing home. The nursing staff loved it because instead of having to apply hand creams to the diaper rash area of the patients, they could just clean the area and spray. All the problems with diaper rash were gone.” • Testimonial from an Emergency Room Physician

10. Soothing for burns • Patients say it relieves burn pain quickly. • Wond-r-Ful’s mechanism of action in pain relief is two-fold: • Firstly, as the solution is alkaline (pH 8.0), it tends to neutralize the acid environment in a burn. • Secondly, the calcium, along with the magnesium, is driven into the cell through the calcium channels, flooding them so that when depolarization occurs in a nerve pain cell at the junction, further diffusion into the nerve terminals is inhibited.

11. Pediatric Study – Pain experienced by burn patients at dressing changes • Pain Control in Pediatric Burn Patients • Red Cross Children's' Hospital • University of Capetown • Capetown, SA • Researcher: Dr. H. Scheinfeld, MD - Trauma Surgeon • Rene Albertyn, RN - Pain Specialist • One of the most distressing problems with burn patients is the pain they experience with dressing changes. A study was undertaken at the Red Cross Children's Hospital in Capetown, South Africa, the teaching hospital of the University of Capetown, to see if a solution called Wond-r-Ful could reduce the pain children experience with dressing changes. • Wond-r-Ful is a solution of Ultra-Pure water, magnesium, sodium, sulfated ester oil of euphoribiacae and trace elements. It is non-carcinogenic, non-mutagenic, and non-irritating to skin and eyes. Its LD50 is greater than 20 grams per kilogram. The solution is also bactericidal to Staph, Strept, E. Coli, and Pseudomonas. • A study with twenty-one (21) children, all over three years old, was undertaken to look at the solution's effect on pain control during dressing changes. The study was double blinded. At each dressing change the patient had his / her dressings soaked in either Normal Saline (which was the hospital solution used to remove adherent burn dressings) or Wond-r-Ful. The bottles were not labeled as to content, only with a code. The only person who knew the code for each bottle was never involved in patient care. • At each dressing change the RN soaked the dressings in either one or the other solution depending on which patient was enlisted to receive which coded solution. The RN noted the amount of pain described by the patient. • RESULT • Over half the cases of those whose dressings were soaked in Wond-r-Ful described no pain at dressing changes, compared to the control group which continued to complain of pain with dressing changes. There was also no increase in the incidences of infection. • CONCLUSION • We found that Wond-r-Ful is a safe, non-toxic solution which does not promote infection, but which reduces or eliminates the pain patients experience with the changing of burn dressings.

12. Great for Patient Care • Spray application - Do not have to touch burn or wound site to apply – easy to use • Promotes rapid healing process in chronic wounds • Soothing and cool • Bacteriocidal • Eases dressing-change pain • Non-irritating to skin and eyes • All natural • Less expensive

13. Open Wound / Pressure Sore Study on Twelve Patients (Handout available – 12 pages)

14. Chronic wound – decubitus (pressure sore) treated with Wond-r-Ful

15. Decubitus sores are hard to heal, but not impossible with patience

16. Healed in 28 days

17. Diabetics must change diet to be completely healed – this one stalled until diet changed

18. Farm accident – burned thigh – sprayed Wond-r-Ful and did nothing else – no bandages or medication

22. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 This presentation is a pictorial summary of a pilot burn study done in Hanoi, Vietnam. Comments from participating doctors are included. The study is part of a test program, the results of which were submitted and accepted by the Vietnam Ministry of Health May-June 1998. Dr. Phan Van Hanh, MD - Coordinator

23. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 The pilot study was undertaken to determine if a sprayed-on solution called Wond-r-Ful, which is bactericidal to Staph, Strept, E.Coli, Pseudomonas, and Salmonella, would be effective in the treatment of second and third degree burns. The doctors in this study have since expanded it to other hospital burn centers.

24. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 The study was presented at an eleven nation burn congress in Hanoi, Vietnam in November 1997

25. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 Burn Study Three patients with second and third degree hot water burns • Experimental Treatment - Sprayed with Wond-r-Ful and covered with gauze - BID • Control Treatment - a Silvadene type cream with gauze - BID

26. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 Comments by Participating Doctors • Healing when using Wond-r-Ful was faster than with standard treatment • The patients did not complain of pain in the burn areas where Wond-r-Ful was used

27. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 Patient 1 Twenty-one year old male suffering from second and third degree hot water burns to the chest and left leg Chest treated with Wond-r-Ful (experimental) Leg treated with Cream (control) Dates of treatment October 31, 1997 through November 9, 1997 Slides VN1 through VN7

28. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 1 / Day 1 • Superior half of burn (chest) sprayed with Wond-r-Ful Slide VN1

29. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 1 / Day 1 • Inferior half of burn (Leg) covered BID with Silvadene type cream Slide VN2

30. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 1 / Day 1 • Chest – Wond-r-Ful Slide VN3

31. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 1 / Day 1 • Leg - Silvadene type cream Slide VN4

32. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 1 / Day 8 • Chest – Wond-r-Ful • Patient has very little if any pain in the burn area • Granulation is well on its way Slide VN5

33. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 1 / Day 9 • Leg - Silvadene type cream • Still a fair amount of pain in the burn area • Granulation tissue is at a minimum Slide VN6

34. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 1 / Day 9 • Chest – Wond-r-Ful Slide VN7

35. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 1 / Day 9 • Chest – Wond-r-Ful • At the border of the Superior and Inferior halves of the burn one can see that the Superior half has good granulation and that the burn is healing well • The Inferior half of the burn area is still very inflamed Slide VN7 (con)

36. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 Patient 2 Fifty-one year old male suffering from second degree hot water burns to the right and left legs Left Leg treated with Wond-r-Ful (experimental) Right Leg treated with Cream (control) Dates of treatment October 25, 1997 through October 27, 1997 Slides VN8 through VN13

37. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 2 / Day 1 • Left Leg – Wond-r-Ful Slide VN8

38. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 2 / Day 1 • Left Leg – Wond-r-Ful Slide VN9

39. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 2 / Day 1 • Right Leg - Silvadene type cream Slide VN10

40. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 2 / Day 1 • Right Leg - Silvadene type cream Slide VN11

41. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 2 / Day 2 • Left Leg – Wond-r-Ful • Very little pain • Good pink tissue forming Slide VN12

42. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 2 / Day 2 • Right Leg - Silvadene type cream • Yellow exudate at inferior aspect of the burn area Slide VN13

43. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 Patient 3 Thirty year old male suffering from second and third degree hot water burns to his back Inferior half treated with Wond-r-Ful (experimental) Superior half treated with Cream (control) Dates of treatment October 25, 1997 through October 29, 1997 Slides VN14 through VN21

44. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 3 / Day 1 • Superior half - Control • Inferior half - Experimental Slide VN14

45. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 3 / Day 1 • Superior half of burn covered with Silvadene type cream and gauze overlaid - BID • Inferior half sprayed with Wond-r-Ful and covered with gauze - BID Slide VN14 (con)

46. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 3 / Day 1 • Inferior half of burn area – Wond-r-Ful Slide VN15

47. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 3 / Day 1 • Superior half of burn area - Silvadene type cream Slide VN16

48. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 3 / Day 1 • Superior half of burn area - Silvadene type cream Slide VN17

49. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 3 / Day 2 • Wond-r-Ful treated area with granulation tissue starting to form • Patient states that pain in the Wond-r-Ful treated area is not “too bad” Slide VN18

50. VIETNAM BURN STUDY October 25, 1997 through November 9, 1997 • Patient 3 / Day 2 • No granulation noted in the superior half of the burn area • A yellow exudate can be seen along the right edge of the blistering Slide VN19