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Project Summary Revisited

Active Asthma Inhaler Annemarie Alderson Annie Saha, Stephanie Shaulis, Bob Toth Project Mentor: Dr. Timothy Corcoran, PhD February 15, 2005. Project Summary Revisited. To design and develop a dry-powder, single-dose, disposable inhaler

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Project Summary Revisited

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  1. Active Asthma InhalerAnnemarie AldersonAnnie Saha, Stephanie Shaulis, Bob Toth Project Mentor: Dr. Timothy Corcoran, PhDFebruary 15, 2005

  2. Project Summary Revisited • To design and develop a dry-powder, single-dose, disposable inhaler • To create a prototype that is self contained, ruggedly constructed, weather and water proof, lightweight, small, ergonomically designed, and actively mobile • To be used for asthmatic individuals that desire a temporary alternative to traditional devices during physical activity and/or in extreme environment settings

  3. Why a Dry-Powder Inhaler? • 70% of patients using MDI’s fail to use them properly • Only about 10%-20% of dose actually reaches the targeted airways with MDI’s; most of medication is caught in the back of the throat • Left: Mold of a human throat made from a cadaver (Courtesy Dr. Corcoran)

  4. Preliminary Prototype Dimensions: 30mm x 20mm x 10mm

  5. Achievements and Milestones to Date • Drug Research, Availability and Purchasing • Obtained USP-grade Albuterol Sulfate from Spectrum Chemical, end of January • Preliminary Particle Size Testing • Results, January 31 • Materials Selection • Contacted Andy Holmes at Swanson • Prototype to be made of ABS Plastic

  6. Preliminary Particle Size Testing • Aerosol medications should have particle size between 2-5 um • Sample readings from albuterol shown below

  7. Work To Do • Further Particle Size Testing of Albuterol • Possibly Particle Size Sorting • Particle Size Testing of Atropine Sulfate obtained through Mentor • Drug Dispersal Testing • Determine Sealing Mechanism • Aesthetic Considerations of Prototype

  8. Possible Obstacles • Sorting albuterol particle size to obtain the smaller particles • Airtight sealing mechanism to prevent contamination/moisture • Drug Dispersal in DPI’s • Questions??

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