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Fibrinogen adsorption on “ arbIBS ”: 256 ng /cm 2 BSA adsorption on “ arbIBS ”: 70.35 ng/cm 2

Surface Modification of Polyisobutylene -based Biomaterials Judit E. Puskas , University of Akron, DMR 0804878.

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Fibrinogen adsorption on “ arbIBS ”: 256 ng /cm 2 BSA adsorption on “ arbIBS ”: 70.35 ng/cm 2

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  1. Surface Modification of Polyisobutylene-based BiomaterialsJudit E. Puskas, University of Akron, DMR 0804878 Intellectual Merit: Techniques for enzymatic polymerization and functionalization are being developed and implemented to synthesize targeted therapeutic and diagnostic drugs and to functionalize the surfaces of biomaterials. A main focus of the research is to independently vary surface topology and chemistry of biomedical implant devices. Protein adsorption studies show potential for arbIBS, a polyisobutylene-based material as an alternative to biomedical silicone rubber. Initial work is underway to study protein adsorption on various functionalized arbIBS surfaces. Past work was presented at the recent 2012 ACS National Meeting and IUPAC World Polymer Congress 2012. Based upon the work and her vision to combat breast cancer, Dr. Puskas was chosen as 1 of 5 winners of General Electric’s “Healthymagination Cancer Challenge” Award in March of 2012. Fibrinogen Fibrinogen adsorption on “arbIBS”: 256 ng/cm2 BSA adsorption on “arbIBS”: 70.35 ng/cm2 Bovine Serum Albumin (BSA) Surface Plasmon Resonance (SPR) traces are shown measuring adsorption of proteins to the surface of arbIBS, a polyisobutylene-based biomaterial. Fibronegen adsorption on arbIBS is less than half of that measured on silicone rubber indicating potential to alter the inflammatory response.

  2. Surface Modification of Polyisobutylene-based BiomaterialsJudit E. Puskas, University of Akron, DMR 0804878 Broader Impacts: Considerable outreach effort was made over the past year to expose undergraduates, and high school students to STEM2education. Over the past year we have had 6 undergraduates from Chemical Engineering, Chemistry, and Biology. We have also had Ms. K. Graham and Mr. J. Friess (High school students) and Mr. D. Chapman (High School Teacher) working within the last year as outreach members. Mr. Friess has worked in our lab for 3 years and has chosen to continue work with our group while pursuing a degree in Chemical Engineering at U. Akron. Dr. Puskas is in the process of having an introductory textbook published on a biological-based approach to polymer chemistry targeted at attracting advanced high school students to polymer chemistry. 10µm Above: Self-supported electrospun fiber mats produced by Mr. Friess are being explored as drug delivery vehicles, implant coatings, and as tissue scaffolds.. Alternately, methods for spray coating iimplant surfaces are also being developed. Above: Mr. Chapman designed and utilized custom-manufactured molds to compression mold arbIBS and similar materials for applications including a self-sealing plug for tissue expanders. Web site: http://gozips.uakron.edu/~jpuskas/

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