Mutations

1. Mutations

2. Definition • A mutation is a change in an organism’s DNA • Silent mutations are changes that do not result in a change to the organisms phenotype • Mutations that occur in germ cells (sperm, eggs) are passed on to offspring • Mutations in somatic (body) cells may be harmless, or may result in disease such as cancer

3. Chromosomal Mutations

4. A Point Mutation Resulting in Nonsense

5. A Point Mutation: An Analogy thereddogbitthetancat theredmogbitthetancat This point mutation changes the meaning, resulting in nonsense

6. A Point Mutation Resulting in Missense

7. A Point Mutation: An Analogy thereddogbitthetancat theredhogbitthetancat This point mutation changes the meaning, resulting in missense

8. An Insertion Mutation in a Gene

9. An Insertion Mutation: An Analogy thereddogbitthetancat theredrdogbitthetanca This insertion mutation changes the reading frame

10. A Deletion Mutation in a Gene

11. An Deletion Mutation: An Analogy thereddogbitthetancat theredogbitthetancat_ This deletion mutation changes the reading frame

12. A Frameshift Mutation