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Testing for Heterogeneity (Sex differences)

Testing for Heterogeneity (Sex differences). Danielle Dick, Hermine Maes , Tim York. Sex Effects. Does the magnitude of genetic/environmental effects differ in males and females?. Sex Effects. Females. Males. Sex Effects. Females. Males.

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Testing for Heterogeneity (Sex differences)

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  1. Testing for Heterogeneity (Sex differences) Danielle Dick, HermineMaes, Tim York

  2. Sex Effects • Does the magnitude of genetic/environmental effects differ in males and females?

  3. Sex Effects Females Males

  4. Sex Effects Females Males aF = aM ? cF = cM ? eF = eM ?

  5. Sex Effects • Does the magnitude of genetic/environmental effects differ in males and females? (QUANTITATIVE) • With OS pairs: Are the same genes/environments acting in males and females (QUALITATIVE)

  6. Sex Specific Effects • Inspecting the correlations from DZ like-sex and opposite-sex pairs can alert you to the presence of sex-specific effects if the OSDZ correlation is markedly less than the SSDZ correlations.

  7. ADE heterogeneity model

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