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CHARM Program: 3 Component trials comparing candesartan with placebo

CHARM Program: 3 Component trials comparing candesartan with placebo. CHARM Program: Baseline characteristics. CHARM Program: Baseline medications. CHARM-Overall: CV death and non-CV death. CHARM Program: Reduction in mortality and morbidity. CHARM Program: Reduction in CHF hospitalization.

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CHARM Program: 3 Component trials comparing candesartan with placebo

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  1. CHARM Program: 3 Component trials comparing candesartan with placebo

  2. CHARM Program: Baseline characteristics

  3. CHARM Program: Baseline medications

  4. CHARM-Overall: CV death and non-CV death

  5. CHARM Program: Reduction in mortality and morbidity

  6. CHARM Program: Reduction in CHF hospitalization

  7. CHARM-Preserved: Hospital admissions for CHF

  8. CHARM-Overall: Effects of candesartan on CV death or HF hospitalization—Subgroup analysis

  9. CHARM-Overall: Effects of candesartan on CV death or HF hospitalization—Subgroup analysis (cont’d)

  10. CHARM-Added: Effect of combined ACE inhibitor/-blocker/AT1-receptor blocker

  11. CHARM-Overall: Drug discontinuations for adverse events

  12. CHARM: Clinical implications

  13. CHARM-Overall: Reduction in new-onset diabetes

  14. CHARM: Impact of treatment

  15. HF with preserved LV systolic function in the elderly: Impact on survival

  16. CHARM-Preserved: CV death or CHF hospitalization

  17. CHARM-Preserved: Primary and secondary outcomes

  18. CHARM-Preserved: Clinical implications

  19. VALIANT: Design

  20. VALIANT: Concomitant medications

  21. VALIANT: Treatments show similar effect on outcome

  22. VALIANT: Clinical implications

  23. VALIANT: Effect of treatment on mortality—Subgroup analysis

  24. RESOLVD: Comparative impact of ACE inhibitor, ARB, and -blocker alone or combined on LVEF

  25. Differences in dosing among ARB trials

  26. Survival studies of -blockade in HF

  27. -Blockers improve survival in diabetic patients with HF: A meta-analysis

  28. MERIT-HF: -Blockade improves survival in CHF

  29. MERIT-HF: -Blockade improves survival in post-MI patients with HF

  30. MERIT-HF: Subgroup analysis in post-MI patients with HF (LVEF <25%)

  31. SOLVD: Heart rate predicts progression of asymptomatic LV dysfunction

  32. MERIT-HF: Effect of -blockade on heart rate

  33. MERIT-HF: -Blockade decreases mortality and hospitalization independent of resting heart rate

  34. CHRISTMAS: Design

  35. CHRISTMAS: Trial profile

  36. CHRISTMAS: Change in LVEF according to number of segments affected by myocardial hibernation

  37. COMET: Trial profile

  38. COMET: All-cause mortality

  39. COMET: Heart rate at each visit

  40. COMET: Blood pressure

  41. -Blocker HF trials: Mortality results

  42. Mortality rates in perspective CIBIS-II, MERIT-HF, COMET

  43. Immediate-release vs sustained release metoprolol: Significant pharmacokinetic differences

  44. COMET: Clinical implications

  45. Comparison of -blocker effects in major HF trials

  46. Not all -blockers are the same

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