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Carbohydrates

Novel Technologies to assess Gut Health Claims for Carbohydrates subtheme: Immunobarrier Paul de Vos (UMCG) p.de.vos@med.umcg.nl. Design a technology platform: to assess health benefits that meet EFSA requirement. Carbohydrates.

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Carbohydrates

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  1. Novel Technologies to assess Gut Health Claims for Carbohydrates subtheme:ImmunobarrierPaul de Vos (UMCG)p.de.vos@med.umcg.nl

  2. Design a technology platform: to assess health benefits that meet EFSA requirement Carbohydrates

  3. Design a technology platform: to assess health benefits that meet EFSA requirement Food enhanced stimulation of epithelial barrier Immunemodulatory Food components Delivery and uptake of fragile vitamines, carbohydrates, fibers etc Food components Stimulating specific immunity/memory

  4. Design a technology platform: to assess health benefits that meet EFSA requirement 1. HTP screening to identify immunemodulating carbohydrates and get insight in stage/mechanism of effect. 2. Testing in appropriate animal model (eg vaccination, allergy, Th1 and Th2 etc) Identification of specific effect: (i) Immune stimulation/suppressing/regulatory (ii) Beneficial for adults, infants, diseased or healthy subjects, male or female Successful compounds will enter subtheme human studies (healthy/adults/infants)

  5. Design a technology platform: to assess health benefits that meet EFSA requirement 1. HTP screening to identify immunemodulating carbohydrates and get insight in stage/mechanism of effect. Assays to measure effect on mucus production/function, Assays to measure effect on gut epithelium (permeability, defensins etc) Assays to measure effect on lymphocytes/dendritics Assays to identify effects on pattern recognition receptors  Combined leads to insight how and where carbohydrates work 2. Testing in appropriate animal model Based on results of 1. in depth analysis on mechanisms in experimental animal studies Vaccination, Pseudomonas, RSV, Rota, influenza, Listeria monoc., Trichinella Spiralis infection models, Allergy models (cow’s milk, henns egg, peanut allergy), DTH models, autoimmune diabetes models, asthma models, COPD models, cachexia models, inflammation models, arthritis (OA)/RA models

  6. Design a technology platform: to assess health benefits that meet EFSA requirement H. Wichers H. Schmidt H. Savelkoul J. Dekker J. Mes H. Schols ........... P. de Vos M.M. Faas H.J. Verkade M. Priebe ........... J. Garssen ........... (expertise: HTP systems, animals models) Other contributing institutes/companies and participants welcome !

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