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Declaration of Relevant Financial Interests or Relationships

ISMRM 20 th ANNUAL MEETING & EXHIBITION “Adapting MR in a Changing World”. Declaration of Relevant Financial Interests or Relationships. Speaker Name: Jennifer Moroz I have no relevant financial interest or relationship to disclose with regard to the subject matter of this presentation.

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Declaration of Relevant Financial Interests or Relationships

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  1. ISMRM 20th ANNUAL MEETING & EXHIBITION “Adapting MR in a Changing World” Declaration of Relevant Financial Interests or Relationships Speaker Name: Jennifer Moroz I have no relevant financial interest or relationship to disclose with regard to the subject matter of this presentation.

  2. Estimation of the Arterial Input Function in a Mouse Tail from the Signal Phase of Projection Profiles J. Moroz, A. Yung, P. Kozlowski, S. Reinsberg University of British Columbia

  3. The Arterial Input Function (AIF) Describes the time course plasma concentration of contrast agent in a vessel Accurate AIF required for modeling * Improve accuracy with higher temporal resolution *

  4. AIF Measurement from Phase Signal Phase Varies linearly with concentration (mod 2p) Greater SNR than signal magnitude Fairly insensitive to T2* relaxation Phase evolves differently in vessels Requires flow compensation

  5. Phase-Concentration Calibration(Projection data) Theoretical Experimental

  6. High Temporal Resolution Improves AIF Accuracy • Rapid enhancement post injection • Curve shape not obvious • Peak concentration? • Peak location? • AIF sampling rates • Mouse • Lyng et al. (1998) – 33 s • Ragan et al. (2010) – 84 ms • Fruytien et al. (2011) – 1.19 s • Rat • McGrath et al. (2009) – 0.5 s

  7. Methods: Mouse Tail Surface Coil Spatial Resolution = 58 mm 1-5 pixels per vessel (projections)

  8. Methods: Use of Projections SolveAIF(t) = (f(t) – fpre-injection) / (Ccalibration* TE)

  9. Results: Projections-based AIF in a Mouse Tail

  10. Expected Functional Form of AIF

  11. Expected FunctionalForm of AIF

  12. Conclusions Early time points of AIF may be dependent on injection protocol Injection protocol must match if using a population averaged result Measure AIF for each experiment AIF may be measured from projection profile Increased temporal resolution Limitation: tissue enhancement Flow compensation required for AIF in mouse tail

  13. Acknowledgements • Funding Agencies • Lab Personnel • Kelly McPhee • Jennifer Baker

  14. Future Plans

  15. Flow Compensation is Required

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