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HUMAN DNA. DNA- genetic information of the cell (Blueprint of Life) * NUCLEIC ACID *. Storing DNA. Chromatin- uncoiled DNA ( store this way during normal cell functions ) Chromosomes- DNA coiled around proteins ( stored this way when the cell reproduces ).
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HUMAN DNA DNA- genetic information of the cell (Blueprint of Life) * NUCLEIC ACID *
Storing DNA • Chromatin- uncoiled DNA (store this way during normal cell functions) • Chromosomes- DNA coiled around proteins (stored this way when the cell reproduces)
In order for a cell to make a new cell it must replicate (copy) its existing chromosomes • Replicated Chromosomes • Sister Chromatids- exact copies of DNA • Centromere- connects sister chromatids Centromere
Karyotype • Photograph of all chromosomes in a cell, arranged by size
Types of Chromosomes • Homologous Chromosomes- two chromosomes that carry the same type of information, but are not identical • Autosomes- non-sex chromosomes • Humans: 22 pairs of autosomes + 1 pair of sex chromosomes = 23 pairs or 46 chromosomes
Cell Cycle- process where cells grow and divide • Important: growth, wound healing, replace cells (old skin cells)….
Cell structures involved in reproduction • Chromosomes • Spindle- protein fibers that move chromosomes • Centrioles- structures that anchor spindle at ends of the cell
NORMAL CELL LIFE CYCLE • INTERPHASE • GROWTH – G1 – growth of organelles • SYNTHESIS – S – synthesis of new DNA • GROWTH – G2 – growth of proteins • MITOSIS • division of duplicated DNA • PMAT – Prophase, Metaphase, Anaphase & Telophase
Stages of Mitosis • Prophase • Chromosomes present themselves; they become visible. • Metaphase • Chromosomes line up in the middle; on equator. • Anaphase • Centromeres divide. Chromosomes move apart • Telophase • Chromosomes uncoil, cytokinesis begins, and becomes two cells.
Mitosis In Action! • Mitosis • Mitosis
CANCER – OUT OF CONTROL CELL GROWTH • BENIGN or MALIGNANT – A difference in activity • METASTASIS – Spread away from the site of origin • Carcinoma, Sarcoma, Leukemia & Lymphoma