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Hepatitis E - Clinical Features

Hepatitis E - Clinical Features. Incubation period: Average 40 days Range 15-60 days Case-fatality rate: Overall, 1%-3% Pregnant women, 15%-25% Illness severity: Increased with age Chronic sequelae: None identified. Hepatitis E Virus Infection. Typical Serologic Course.

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Hepatitis E - Clinical Features

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  1. Hepatitis E - Clinical Features • Incubation period: Average 40 days • Range 15-60 days • Case-fatality rate: Overall, 1%-3% Pregnant women, 15%-25% • Illness severity: Increased with age • Chronic sequelae: None identified

  2. Hepatitis E Virus Infection Typical Serologic Course Symptoms ALT IgG anti-HEV IgM anti-HEV Titer Virus in stool 0 1 2 3 4 5 6 7 8 9 10 11 12 13 Weeks after Exposure

  3. Hepatitis E - Epidemiologic Features • Most outbreaks associated withfecally contaminated drinking water • Minimal person-to-person transmission • U.S. cases usually have history of travelto HEV-endemic areas

  4. Geographic Distribution of Hepatitis E Outbreaks or Confirmed Infection in >25% of Sporadic Non-ABC Hepatitis

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