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Biotechnology

Biotechnology. Thermal “Needs”. Paul Nesvadba EVITHERM meeting at PTB Berlin, 17 th May 2004. Biotechnology. Technology of 21 st century Practical applications of biological organisms or their components Genetic engineering, genomics, proteomics, transgenic crops and animals

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Biotechnology

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  1. Biotechnology Thermal “Needs” Paul Nesvadba EVITHERM meeting at PTB Berlin, 17th May 2004

  2. Biotechnology • Technology of 21st century • Practical applications of biological organisms or their components • Genetic engineering, genomics, proteomics, transgenic crops and animals • Brewing beer, treatment of sewage, wastewater, drug development, agriculture

  3. Fields of Biotechnology • Molecular / Cell Biology • Biochemistry • Genetics / Genomics / Proteomics • Immunology • Microbiology / Virology • Biological/ Biochemicals/ Chemicals Manufacturing • Pharmaceutical Science & Research • Plant Sciences / Agribiotech • Bioprocessing / Bioengineering • Ecology / Environment • Diagnostics • Food & Drink • Bioinformatics • Vaccines

  4. Molecular Biology & Bioinformatics • Genetic and Molecular basis of disease • Gene editing (e.g. GM crops) • Discovery systems (e.g. drug discovery) • Protein separation and fusion systems • Antibody engineering • High throughput

  5. Heat and Temperature • “Bioinformatics” • Low energy, high precision of control (e.g. PCR - polymerase chain reaction) • Large scale Industrial processes • High energy consumption • Optimisation • Knowledge for reducing environmental impact

  6. “Hardware” in Biotechnology Laboratory • PCR Thermocyclers • Tissue Culture - Incubators Industrial • Vaccines / Pharmaceuticals – TTIs - TIs • Fermenters – heat removal! • Waste treatment plants

  7. Industrial Fermentation • The optimum fermentation temperature is about 32 °C • The heat of formation of ethanol is 1.2 MJ / kg of ethanol • Cooling is necessary in order for the yeast to survive and work efficiently

  8. Brewing • The oldest biotechnology process • 8000 years ago in Babylon • Today’s large scale brewing is highly sophisticated • Involves many heating and cooling steps

  9. Heat Exchangers • Energy efficiency (higher heat transfer coefficient, recycling) • Small size, low mass, easy capacity modification • Ease of cleaning • Shell-and-tube exchangers (traditional) • Plate

  10. Tubular Heat Exchanger (Alfa Laval Viscoline TM) • Heating, cooling, heat regeneration • Pasteurisation • UHT treatment of viscous fluids

  11. Plate Heat Exchanger (Alfa Laval)

  12. Waste Water Treatment • The need for efficient handling of wastewater and sludge is increasing worldwide.

  13. Objective: To reduce the volume of wastewater • Processes and equipment • Decanter centrifuges for dewatering • Spiral heat exchangers • Heating, cooling, heat recovery and pasteurisation • Drum thickeners/dryers for sludge volume reduction • Decanter autopilot optimising plant operation

  14. Compilation of contacts • Alfa Laval (UK, Sweden) • Biometra Gmbh (Göttingen, Germany) • BioProcess Engineering Services Ltd (UK) • GE Healthcare and GE Bio-Sciences (UK) • Grant Instruments (Cambridge, UK) • New Brunswick Scientific (UK) Ltd • Thermo Electron Corporation (USA) • Technical University Berlin, Inst. Food Technology

  15. Conclusions • Biotechnology • Large area • Diverse processes • Scale from laboratory to industrial • Identification of users in need of EVITHERM • Started compiling a list of users • Contacting users

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