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Allergy Urticaria Angioedema Shock anaphylactic

Allergy Urticaria Angioedema Shock anaphylactic. Allergy . Antigens: Endogens Exogens : 1-drugs 2-infections 3-foods 4-physical Ag 5-contact allergens 6-inhalars. Antibodies( Ig ) IgG IgM IgA IgD IgE. Allergic reaction . 1-Immediat type: Anaphylaxis Rhinitis allergic

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Allergy Urticaria Angioedema Shock anaphylactic

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  1. Allergy UrticariaAngioedemaShock anaphylactic

  2. Allergy • Antigens: • Endogens • Exogens: 1-drugs 2-infections 3-foods 4-physical Ag 5-contact allergens 6-inhalars • Antibodies(Ig) • IgG • IgM • IgA • IgD • IgE

  3. Allergic reaction 1-Immediat type: • Anaphylaxis • Rhinitis allergic • Allergic bronchial asthma 2-delayed type: • Tuberculin type • Contact type • Auto allergic reaction • Graft versus host reaction

  4. Allergic test Allergic tests contraindication • Patch test • Scratch test • Intradermal test • Asthma bronchial attack • Generalized urticaria • Rhinitis allergic……..

  5. Urticaria & hives

  6. Etiology & pathogenesis • Mast cell degranulation • Vasodilatation and increase permeability • Wheal formation

  7. dermal mast cell granules

  8. Urticaria classification • Acuturticaria • Recurrent acute urticaria • Chronic urticaria(90%)etiology is unknown

  9. clinical features • Localized urticaria • Generalized urticaria

  10. Dermatographism • Sharply localized wheal and flare seconds to minutes after stroking skin. • 25% to 50% of the population

  11. Dermographisim

  12. Pressure Urticaria • 3-12 hours after local pressure has been applied • feet/walking and buttocks/sitting

  13. Cholinergic urticaria

  14. Solar urticaria: • Occur a few minutes to few hours after exposure to sun light. • Usually fade within 2 hours.

  15. Cold Urticaria • Holding cold objects: hand swelling • Eating cold items: lip swelling/ oropharyngeal edema • Swimming, with total body immersion, can result in massive mediator release, resulting in hypotension • Attacks occure within minutes after exposure to change in ambient temperature or direct contact with cold objects.

  16. Cold Urticaria • 25% patients are atopic • Desensitize: repeated colder exposures • Test: Ice cube 5-20min.

  17. Angio-oedema • It may be associated in 50% of patients with ordinary urticaria. • Deep swelling, maybe the same colour as normal skin. • Most frequently occur on face, but any other area of the body may be affected.

  18. Angioedema

  19. Shock anaphylactic • Usually in atopics • Usually the allergen is antibiotic injection

  20. Diagnosis & Differential diagnosis • Erythema multiform • Urticaria papulosa • UrticarialVasculitis (persist Urticaria) • BullousPemphigoid • Sarcoidosis • Most of the diseases listed above have lesions that last longer than 24 hours

  21. Treatment • Acute urticaria • H1 blocker anti histamins sedating and non sedating • Prednisolon • Epinephrin 1mg/IM • Avoid precipitating factors • In chronic state: avoid steroid therapy.

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