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This study examines the relationship between the structures surrounding the NB-cluster and the impact on the activity of NB-protein mutants. The research conducted by N. Muraki et al. in Nature highlights the significant role of structural configurations in influencing the functionality of NB-proteins. By analyzing the complex interplay between these structures and mutant proteins, the study sheds light on potential mechanisms underlying the observed activity variations. Understanding these relationships is crucial for deciphering the underlying molecular processes and developing targeted therapeutic approaches.
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Structures around the NB-cluster and the activity of NB-protein mutants. N Muraki et al.Nature000, 1-5 (2010) doi:10.1038/nature08950